摘要
目的:本研究通过检测血清降钙素原(PCT)水平的变化,探讨PCT在小儿社区获得性肺炎(CAP)诊治中的临床意义。方法:选取我院97例确诊为CAP的患儿,分为细菌感染性CAP组(47例,A组),非细菌感染性CAP组(50例,B组),另选取我院门诊体检健康儿童作为健康对照组(45例,C组),检测各组患儿治疗前与治疗后以及A组内重症感染者(D组)与非重症感染者(E组)血清PCT水平并比较其变化。结果:(1)A组PCT水平显著高于B组及C组(P<0.05)。(2)A组及B组C反应蛋白(CRP)水平、白细胞(WBC)计数显著高于C组(P<0.05),A组与B组CRP水平、WBC计数比较差异无统计学意义(P>0.05)。(3)D组PCT水平显著高于E组(P<0.05)。(4)治疗后A组PCT、CRP水平以及WBC计数较治疗前明显下降,治疗后B组CRP水平及WBC计数较治疗前明显下降,差异均有统计学意义(P<0.05)。结论:血清PCT对小儿细菌感染性CAP与非细菌性感染CAP鉴别诊断有指导意义,且对感染严重程度有一定评估作用。
Objective： To research the clinical value of procalcitonin（ PCT） in children with community-acquired pneumonia（ CAP）.Methods： Children were divided into three groups： bacteria CAP group（ n = 47,group A）,non-bacteria CAP group（ n = 50,group B）and normal control group（ n = 45,group C）. The levels of serum PCT before and after treatment in three groups and in serious infection children of group A（ group D） and non-serious infection children of group A（ group E） were measured. Results：（ 1） The level of serum PCT in group A was higher than that of group B and group C（ P0. 05）.（ 2） The levels of CRP and WBC in group A and group B were higher than those of group C（ P0. 05）,there were no significant differences between group A and group B（ P0. 05）.（ 3） The levels of PCT in group D were higher than those of group E（ P0. 05）.（ 4） The levels of PCT,CRP and WBC were significantly lower in group A after treatment（ P0. 05）,while the levels of CRP and WBC were significantly lower in group B after treatment（ P0. 05）. Conclusion：Serum PCT was significant for clinical diagnosis of children with CAP,and it can reflect the severity of disease.
出处
《儿科药学杂志》
CAS
2016年第6期11-13,共3页
Journal of Pediatric Pharmacy
关键词
降钙素原
社区获得性肺炎
C反应蛋白
procalcitonin
community-acquired pneumonia
C-reactive protein
