摘要
目的:探讨槐杞黄颗粒辅助治疗小儿咳嗽变异性哮喘的临床疗效及其对机体免疫功能的影响。方法:将我院收治的咳嗽变异性哮喘患儿随机分为槐杞黄颗粒组和常规治疗组,常规治疗组给予支气管扩张剂、白三烯拮抗剂等常规治疗,槐杞黄颗粒组在常规治疗基础上给予槐杞黄颗粒治疗。治疗3个月后,比较两组患儿的临床疗效,观察咳嗽症状缓解及消退时间、外周血免疫球蛋白水平、T淋巴细胞亚群水平以及IFN-γ、IL-4水平的变化;随访6个月,观察患儿咳嗽变异性哮喘的复发情况。结果:两组患儿咳嗽症状缓解时间及临床疗效比较差异无统计学意义(P>0.05),槐杞黄颗粒组咳嗽消退时间明显短于常规治疗组(P<0.01)。治疗3个月后,两组患儿血清Ig A、Ig G水平较治疗前明显升高,Ig E水平明显降低,且槐杞黄颗粒组改善更为明显;除常规治疗组CD8+T淋巴细胞水平改善不明显外,两组患儿T淋巴细胞亚群其他相关指标均较治疗前明显改善,且槐杞黄颗粒组改善更明显;两组患儿血清IFN-γ水平及IFN-γ/IL-4值均较治疗前明显升高,IL-4水平明显降低,且槐杞黄颗粒组改善更为明显(P<0.05)。槐杞黄颗粒组治疗后6个月复发率明显低于常规治疗组(χ2=4.841,P<0.05)。结论:在常规治疗基础上加用槐杞黄颗粒治疗小儿咳嗽变异性哮喘,能提高近期疗效,缩短咳嗽症状缓解及消失时间,更好地促进患儿免疫功能的恢复,降低复发率。
Objective： To investigate the clinical curative effect and the influence of immune function in children with cough variant asthma,who treated with Huaiqihuang particle. Methods： All children with cough variant asthma of our hospital were randomly divided into Huaiqihuang particle group and conventional treatment group,conventional treatment group was given conventional treatment such as bronchodilator,leukotrienes antagonist,etc. Huaiqihuang particle group was given Huaiqihuang particle on the basis of conventional treatment. After 3 months＇ treatment,comparatively analyzed the clinical curative effect of the two groups,observed and recorded the alleviation and fading away time of cough symptoms,the changes of peripheral blood immunoglobulin,the levels of T lymphocyte subsets and IFN-γ,IL-4. The recurrence of cough variant asthma was observed after 6 months. Results： The average alleviation time of cough and the clinical curative effect of the two groups had no statistically significant difference（ P 0. 05）,the average fading away time of cough in Huaiqihuang particle group was obviously shorter than conventional treatment group（ P0. 01）. After 3 months＇ treatment,the levels of Ig A,Ig G in two groups were significantly increased than the treatment before,the Ig E level decreased obviously,and Huaiqihuang particle group improved more obviously. In addition to CD8＋T cells level improvement of conventional treatment group was not obvious,the related indicators of T lymphocyte subsets in both groups were obviously improved,and improved more obviously in Huaiqihuang particle group. The IFN-γ level and IFN-γ / IL-4 ratio of the two groups were significantly increased after treatment,IL-4level decreased obviously,and improved more obviously in Huaiqihuang particle group（ P0. 05）. The recurrence rate of Huaiqihuang particle group was significantly lower than the conventional treatment group after 6 months（ P 0. 05）. Conclusion： Huaiqihuang particle can not only improve the recent curative effect,but also obviously shorten the cough symptoms and fading away time,promote the recovery of the immune balance,reduce the recurrence rate.
出处
《儿科药学杂志》
CAS
2016年第6期22-25,共4页
Journal of Pediatric Pharmacy
关键词
槐杞黄颗粒
咳嗽变异性哮喘
免疫功能
Huaiqihuang particle
cough variant asthma
immune function
