摘要
Chemerin是新发现的脂肪因子,它主要以自分泌或旁分泌的形式由脂肪组织分泌。Chemerin可通过与其受体结合,募集炎性细胞,调节胰岛素的敏感性和脂肪细胞分化,从而对糖脂代谢产生影响。因此,Chemerin可能在肥胖及代谢综合征中起重要作用。此外,Chemerin与心血管疾病、肿瘤、非酒精性脂肪性肝病、多囊卵巢综合征、银屑病等密切相关,且有可能成为相关疾病治疗的新靶点。
Chemerin,identified as a novel adipokine,is mainly secreted from adipocyte by autocrine or paracrine ways. Chemerin has an impact on glucose and lipid metabolism cause it can recruit inflammatory cells,regulate insulin sensitivity and promote adipocytes differentiation via its own receptor. Thus,it may play an important role in obesity and metabolic syndrome. Meanwhile,chemerin is also closely related to cardiovascular disease,cancer,non-alcoholic fatty liver disease,polycystic ovary syndrome,psoriasis,etc. It may become a new target for the treatment of the related diseases.
出处
《医学综述》
2016年第11期2102-2106,共5页
Medical Recapitulate
