摘要
目的研究抗衰老关键蛋白（fibulin5）在子宫内膜癌组织中的表达及其生物学意义。方法利用免疫组化sP法分别对20例正常子宫内膜组织、20例不典型增生子宫内膜组织、40例子宫内膜癌组织中fibulin5的表达情况进行检测，并分析fibulin5与子宫内膜癌临床病理特征的关系。结果fibulin5在正常子宫内膜组织、不典型增生子宫内膜组织、子宫内膜癌组织中阳性表达程度逐渐降低（P〈0．05），且各组间差异有统计学意义。fibulin5在不同病理分期、不同病理分级、不同肌层浸润深度、有无淋巴结转移病例中表达率之间比较差异均有统计学意义（P〈0．05）。结论fibulin5的表达减少或缺失可能与子宫内膜癌的发生发展及侵袭、转移、预后有关。
Objective To investigate the expression and of fibulin5 in endometrial carcinoma and its biological significance. Methods Samples were collected from 20 normal endomedium, 20 endometrial atypical hyperplasia, and 40 endometrial carcinoma to determine their level of fibulin5 by immunohistochemical SP method, and analyzed the relation- ship between fibulin 5 and the clinical characteristics of endometrial carcinoma. Results The quantity of fibulin5 were significantly reduced in endometrial carcinoma and endometrial atypical hyperplasia than those from patients with normal endometrium （P 〈 0.05）. Meanwhile, remarkable difference was found in the positive rate of fibulin5 among patients at different surgical pathologic stages, different pathological grades, different depths of myometrial invasion and with or with- out lymph node metastasis （P 〈 0.05）. Conclusion The loss of expression of fibulin5 might be related with the devel- opment, invasion, metastasis and prognosis endometrial of endometrial carcinoma.
出处
《徐州医学院学报》
CAS
2016年第5期335-338,共4页
Acta Academiae Medicinae Xuzhou
