摘要
目的探讨孕早期妇女低碘摄入量与其患低甲状腺素血症之间的相关性,为孕早期妇女分类指导、科学补碘政策提供依据。方法随机抽取各调查点共计1 165名孕早期（孕0~13周）妇女进行尿碘、血清促甲状腺激素（thyroid stimulating hormone,TSH）、血清游离甲状腺素（free thyroxine,FT4）检测,采用酸消化砷-铈接触法测定尿碘,化学发光法测定TSH、FT4。结果杭州市孕早期妇女尿碘中位数（MUI）为135.18μg/L,重度（MUI〈20μg/L）、中度（20μg/L≤MUI≤50μg/L）、轻度碘缺乏（50μg/L〈MUI〈150μg/L）者分别占1.48%（17/1 165）、8.15%（95/1 165）、47.38%（552/1 165）;农村孕早期妇女不同碘摄入量组间低甲状腺素血症总体患病率差异有统计学意义（χ2=6.849,P=0.033）,低碘摄入量组患病率明显高于适宜碘摄入量组（7.95%vs 1.94%,P=0.009）,其发生低甲状腺素血症的危险性是后者的4.11倍（95%CI：1.268~13.316）。结论杭州市孕早期妇女处于轻度碘缺乏状态,经济欠发达的农村地区孕早期妇女低碘摄入量可增加其患低甲状腺素血症的风险,因此建议对农村孕早期妇女采取碘补充剂干预,并加强其尿碘及甲功的监测。
Objective To explore the correlation between hypothyroxinemia and low iodine intake in early pregnant women and to provide the scientific evidence for iodine supplement. Methods A total of 1 165 early pregnant women（0-13weeks）were randomly enrolled into the study.Their urine and blood samples were collected for the detection of urinary iodine level,serum thyroid stimulating hormone（TSH）and free thyroxine（FT4）by using arsenic-cerium contact process method and chemiluminescence method. Results The median level of urinary iodine was 135.18μg/L,and women with severe,moderate and mild iodine deficiency accounted for 1.48%（17/1 165）,8.15%（95/1 165）and 47.38%（552/1 165）,respectively.The difference of prevalence of hypothyroxinemia among early pregnant women with different iodine intake in rural area was significant（χ2=6.849,P=0.033）.The prevalence of hypothyroxinemia was higher among women with low iodine intake compared to those with normal iodine intake（7.95%vs 1.94%,P=0.009）,and the risk of hypothyroxinemia was 4.11 times higher（95%CI：1.268-13.316）. Conclusions Women in early pregnancy in Hangzhou city are in mild iodine deficiency.Low iodine intake may increase the risk of hypothyroidism in early pregnant women in rural areas.Therefore,it is suggested to take iodine supplement and to enhance the monitoring of urinary iodine and thyroid function.
出处
《中国预防医学杂志》
CAS
2016年第5期361-364,共4页
Chinese Preventive Medicine
基金
杭州市卫生科技计划项目(2014A65)
