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妊娠期糖尿病合并单纯低甲状腺素血症的围产结局分析 被引量:4

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摘要 目的 :探讨妊娠期糖尿病(gestational diabetes mellitus,GDM)孕妇孕中期合并单纯低甲状腺素血症对孕晚期相关不良围产结局的影响。方法:选取400例GDM妇女和400例正常妊娠妇女,在妊娠25周左右检测促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)和抗甲状腺过氧化物酶抗体(TPOAb)的浓度,比较GDM妇女和正常妊娠妇女孕中期甲状腺激素各项指标以及甲状腺功能减退发生率,再挑选出GDM合并孕中期单纯低甲状腺素血症的孕妇作为A组;甲状腺功能正常的GDM孕妇为B组;所有纳入组的研究对象均跟踪随访至分娩,统计孕晚期子痫前期、早产、胎儿窘迫、低出生体重儿的发病情况,比较A组和B组的差别。结果:GDM组孕中期TSH水平高于正常孕妇组,FT4水平低于正常孕妇组,且单纯低甲状腺素血症发生率明显高于正常孕妇组(P均<0.05);TPOAb阳性的孕妇孕中期TSH水平明显高于TPOAb阴性的孕妇(P<0.05);A组孕晚期子痫前期和低出生体重儿的发生率明显高于B组(P均<0.05)。结论 :GDM孕妇孕中期易合并单纯低甲状腺素血症,并可使孕晚期发生相关不良围产结局的风险增加,故建议及时治疗。
作者 田静 徐宜清
出处 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2016年第4期505-507,共3页 Journal of Nanjing Medical University(Natural Sciences)
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参考文献7

  • 1贺译平,贺同强,徐钊,徐叶红,王环,申远,米阳.妊娠20周前甲状腺功能异常对妊娠影响的研究[J].中国妇幼健康研究,2013,24(5):695-697. 被引量:36
  • 2曹泽毅.中华妇产科[M].3版.北京:人民卫生出版社,2014:570-575.
  • 3谢幸.妇产科学[M].8版.北京:人民卫生出版社,2012:374-386.
  • 4Stagnaro-Green A,Abalovich M,Alexander E,et al. Guide- lines of the American Thyroid Association for the diagno- sis and management of thyroid disease during pregnancy and postpartum [ J ]. Thyroid, 2011,21 (10) : 1081-1125.
  • 5Dichtel LE,Alexander EK. Preventing and treating mater- nal hypothyroidism during pregnancy[J]. Curt Opin En- docrinol Diabetes Obes, 2011,18 (6) : 389-394.
  • 6Henrichs J,Bongers-Schokking JJ,Schenk JJ,et al. Mater- nal thyroid function during early pregnancy and cognitive functioning in early childhood:the Generation R study [J]. J Clin Endocrinol Metab, 2010,95(9) :4227-4234.
  • 7Li Y, Shan Z,Teng W, et al. Abnormalities of maternal thyroid function during pregnancy affect neuropsychologi- cal development of their children at 25-30 months [J]. Clin Endocrinol (Oxf) ,2010,72(6) :825-829.

二级参考文献17

  • 1王允锋,杨慧霞.妊娠合并甲状腺功能低减患者的临床分析[J].中华妇产科杂志,2007,42(3):157-160. 被引量:38
  • 2Shan Z Y, Chen Y Y, Teng W P, et al. A study for maternal thyroid hormone deficiency during the first half of pregnancy in china [ J ]. Eur J Clin Invest, 2009, 39 : 37-42.
  • 3Negro R, Schwartz A, Gismndi R, et al. Universal screening versus case finding for detection and treatment of thyroid hormone dysfunction during pregnancy [J]. J Clin Endocrinol Metab, 2010, 95 : 1699-1707.
  • 4中华人民共和国卫生部.妊娠期糖尿病诊断[s].中华人民共和国卫生行业标准,wS331-2011:1-4.
  • 5Ghalia A, Nerea M, Micheal R, et al. Maternal thyroid function at 11 to 13 weeks of gestation and subsequent fetal death I J]. Thyroid, 2010,20:989-993.
  • 6Horacek J, Spitalnikova S, Dlabalova B, et al. Universal screening detects two- times more thyroid disorders in early pregnancy than targeted high-risk case finding[J]. Eur J Endocrinol,2010,163:645- 650.
  • 7Wang W, Teng W, Shan Z, et al. The prevalence of thyroid disorders during early pregnancy in china: The benefits of universal screening in the first trimester of pregnancy [ J ]. Eur J Endocrinol, 2011,164 : 263- 268.
  • 8Cleary-Goldman J, Malone F D, Lambert-Messerlian G, et al. Maternal thyroid hypofunction and pregnancy outcome [ J ]. Obstet gynecol, 2008,112 : 85-92.
  • 9Mannisto T, Vaarsmaki M,Pouta A, et al. Thyroid dysfunction and auto- antibodies during pregnancy as predictive factors of pregnancy complications and maternal morbidity in later life [ J ]. J Clin Endocrinol Metab,2010,95 : 1084-1094.
  • 10Abbassi-Ghanavati M,'Casey B M, Spong C Y, et al. Pregnancy outcomes in women with thyroid peroxidase antibodies [J]. Obstet Gynecol, 2010,116 : 381-386.

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