摘要
心力衰竭(HF)是多种心血管疾病的终末阶段。研究发现,HF患者的甲状旁腺激素(PTH)水平明显增高;基础研究证实PTH、血管紧张素Ⅱ和醛固酮之间存在显著的交互作用,可能参与HF的发病。本文就PTH与HF的关系以及其参与HF发病的可能机制进行综述,以期将PTH作为HF的新标记物和临床干预靶点积累资料。
Heart failure（HF）is the end stage of most cardiovascular diseases. Increasing evidence indicates that serum parathyroid hormone（PTH）is significantly elevated in patients with HF. Experimental studies confirm that there is a significant interaction between PTH,angiotensin Ⅱ and aldosterone,which may be involved in the pathogenesis of HF. This article reviews the relationship between PTH and HF and the possible mechanisms involved in the pathogenesis of HF,in order to accumulate the data of PTH as a new marker and clinical intervention target of HF.
出处
《中国动脉硬化杂志》
CAS
北大核心
2016年第6期629-632,共4页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金(30960137
81460084)
大理大学博士启动基金(2014-21)
大理大学大学生创新项目(X-CXCY2015-11)
关键词
甲状旁腺激素
心力衰竭
钙
醛固酮
Parathyroid Hormone
Heart Failure
Calcium
Aldosterone
