摘要
目的:研究左乙拉西坦治疗儿童癫痫的临床疗效。方法:将68例癫痫患儿随机均分成对照组和观察组,予对照组丙戊酸钠治疗,予观察组左乙拉西坦治疗,比较2组的不良反应事件、临床疗效和安全性,并比较2组患儿治疗后的生活质量情况。结果:观察组治疗的总有效率为91.18%,明显高于对照组的70.59%;观察组治疗过程中的不良反应发生率为11.76%,明显低于对照组的32.35%;观察组患者治疗后的生活质量评分(80.63±7.02)明显高于对照组(63.37±5.96),差异具有统计学意义(P<0.05)。结论:在儿童癫痫的治疗过程中,左乙拉西坦不但具有疗效高、不良反应少、安全性高等特点,而且还能够明显改善患儿的生活质量,有临床推广应用价值。
[Objective]To study the clinical curative effect of levetiracetamin treatingchildren with epilepsy,as well as its impact on quality of life of patients. [Method]68 cases of children with epilepsy were randomly divided into control group and observation group with 34 cases in each group. The control group received treatment of sodium valproate,and the observation group received treatment of levetiracetam. The adverse events,clinical curative effect and safetywere compared between the two groupsand the quality of life was compared by QOLCE.[Result]The total efficiency of observation group was 91. 18%,that significantly higher than 70. 59% of control group; and the incidence of adverse events of observation group was 11. 76%, that was significantly lower than 32. 35% of control group; and the quality of life of observation group were 80. 63 ± 7. 02, that significantly higher than 63. 37 ± 5. 96 of control group,and the differences were statistically significant（ P〈0. 05）.[Conclusion]During treatment of epilepsy in children,levetiracetam not only has higher efficacy,less adverse reactions and higher security features,but also can improve the quality of life of children significantly,and should be vigorously promoted in the future.
出处
《浙江医学教育》
2016年第3期51-53,56,共4页
Zhejiang Medical Education
关键词
左乙拉西坦
癫痫
生活质量
levetiracetam
epilepsy
quality of life
