摘要
目的:研究Nd:YAG激光在LLLT模式下联合局部用药对中老年患者两种类型口腔扁平苔藓的疗效。方法:将17例口腔扁平苔藓患者根据患病类型分为糜烂组及非糜烂组,每种类型患者的左侧病损区为对照组,右侧病损区为实验组。对照组仅以激光照射病损区域,而实验组在病损区域涂抹相应药物后再进行激光照射,分别在治疗前及治疗后0、1、3、6周评价病损区域的面积缩小率及疼痛指数。结果:两种疗法均有助于减少患者的病损面积,但1周内实验组疗法均较对照组显著提高了两类患者的病损面积缩小率(P<0.05),而两类患者分别经两种疗法治疗3周后的病损面积缩小率间均无显著的统计学差异(P>0.05)。两种疗法均显著降低了两类患者的疼痛指数(P<0.05),但两种疗法在各时间点均无显著的统计学差异(P>0.05)。结论:两种疗法对糜烂型及非糜烂型口腔扁平苔癣患者均有显著的疗效,但激光治疗联合局部用药可显著提高两类患者的早期疗效。
Objective： To explore the curative effect of Nd： YAG laser combining local drug administration in the treatment of middle-elderly patients with two types of oral lichen planus. Methods： 17 patients with oral lichen planus treated in our department were selected and divided into erosive type and non-erosive type according to clinical manifestation. The left disease areas of patients with oral lichen planus of each type were divided into control group,which was only given laser treatment. The right disease areas of patients with oral lichen planus of each type were divided into experimental group,which was given laser treatment combining local drug administration. The disease area reduction rate and pain index were evaluated before treatment and 0,1,3,6 weeks after treatment, respectively. Results：The above two treatments can both reduce disease areas of all patients. However, the experimental treatment significantly increased the disease area reduction rate of patients with any type of oral lichen planus within 1 week（P〈0.05）. There was no statistically significant difference on the disease lesion area reduction rate between the two treatments on patients with any type of oral lichen planus after 3 weeks（P〉0.05）. The two treatments both significantly reduced pain index of two types of patients（P〈0.05）. However, there was no statistically significant difference on the pain index between the two treatments on both types of patients at any time points. Conclusion： The two treatments both have remarkable curative effect for patients with erosive type or non-erosive type oral lichen planus. But laser treatment combining local drug administration can significantly increase the early curative effect for two kinds of patients.
出处
《中华老年口腔医学杂志》
2016年第3期155-159,共5页
Chinese Journal of Geriatric Dentistry
基金
兰州军区医药卫生课题面上项目(项目编号:CLZ13JB13)
中科院兰州化学物理研究所国家重点实验室开放课题(项目编号:LSL-1309)
