摘要
目的分析高级别脑内神经胶质瘤术后生存期限的影响因素。方法选择2008-01—2012-12手术治疗的Ⅲ、Ⅳ级脑内神经胶质细胞瘤256例,进行定期随访,统计术后24个月生存率,并分析其影响因素。结果Ⅲ、Ⅳ级脑内神经胶质细胞瘤患者术后24个月生存率为46.09%(118/256),小脑、直径>5cm、Ⅳ级、KPS评分<70、Ki67指数阳性、术后规范放疗脑内神经胶质瘤术后>24个月生存率明显低于大脑、直径≤5cm、Ⅲ级、KPS评分<70、Ki67指数阴性、术后不规范放疗者,差异有统计学意义(P<0.05)。肿瘤部位、肿瘤大小、病理分级、KPS评分、Ki67指数、术后辅助放疗是脑内神经胶质瘤术后生存期限独立危险因素(OR=0.529、1.048、0.179、1.798、0.886、1.046,P<0.05)。结论高级别脑内神经胶质瘤术后24个月生存率较低,发病部位、肿瘤大小、病理分级、KPS评分、Ki67指数、术后辅助放疗是其生存期限的独立危险因素。
Objective To analyze the high grade brain glioma influence factors postoperative survival period.Methods Totally 256 cases ofⅢ,Ⅳ grade brain glioma treated by operation who were followed up regularly from January 2008 to December 2012 were selected,the survival rates of postoperative 24 months were counted,and the influence factors were analyzed.Results The survival rate was 46.09%（118/256）of the Ⅲ,Ⅳ grade brain glioma patients postoperative 24-month,the brain glioma postoperative survival rate was significantly lower whose cerebellar diameter5cm,grade Ⅳ,KPS score70,Ki67 index was positive and postoperative radiotherapy was standardized than that of the brain,the diameter≤5cm,Ⅲ grade,KPS score70,Ki67 index was negative,and postoperative radiotherapy was not standardized,so the difference was statistically significant（P〈0.05）.The tumor location,tumor size,pathological grade,KPS score,Ki67 index,postoperative adjuvant radiotherapy were independent risk factors（OR=0.529,1.048,0.179,1.798,0.886,1.046,P〈0.05）for survival period of brain glioma postoperative.Conclusion The survival rate is lower in high grade brain glioma patients postoperative 24-month,and the tumor size,pathological grade,KPS score,Ki67 index,postoperative adjuvant radiotherapy are independent risk factors of survival period.
出处
《中国实用神经疾病杂志》
2016年第11期19-21,共3页
Chinese Journal of Practical Nervous Diseases
