摘要
目的分析帕金森病患者周围神经病变与血清叶酸、维生素B12水平的相关性。方法随机选取100例帕金森病患者为病例组,同时选取与病例组性别、年龄、身体条件、生活区域相似的100例健康人为对照组,比较2组周围神经病变的发病情况以及血清叶酸、维生素B12水平。结果病例组周围神经病变发病率42.0%,对照组为16.0%,病例组明显高于对照组(P<0.05)。病例组尺神经、正中神经传导速度虽较对照组有所降低,但差异无统计学意义(P>0.05);病例组周围神经受损者的腓肠神经、胫神经传导速度明显较对照组低(P<0.05),但病例组无周围神经受损者的腓肠神经、胫神经传导速度较对照组虽有所降低,但只与对照组无周围神经受损者差异有统计学意义(P<0.05)。对照组维生素B12以及叶酸的浓度较病例组高,且其浓度与病例组患者的周围神经受损程度有明显的正相关性;病例组无周围神经受损者的维生素B12以及叶酸浓度较对照组中周围神经受损者低(P<0.05)。结论帕金森病患者周围神经病变与血清叶酸、维生素B12水平呈负相关,患者血清叶酸、维生素B12水平越低,发生周围神经病变的可能性越大,病情越重。
Objective To analyze the relationship between peripheral neuropathy in patients with Parkinson＇s disease and the levels of serum folate,vitamin B12.Methods Clinical data of patients with Parkinson＇s disease（case group）in our hospital from December 2012 to December 2014 was retrospectively analyzed.One hundred healthy people who were similar to the case group with the gender,age,physical condition and the area of life were chosen as the control group.The incidence of peripheral neuropathy,and the levels of serum folate,vitamin B12 in two groups were compared.Results The incidence of peripheral neuropathy in case group was 42.0percent,and the control group was 16.0percent.The incidence of peripheral neuropathy in case group was obviously higher than that in control group,and the differences had statistical significance（P〈0.05）.The conduction velocity of median nerve,ulnar nerve in case group were lower than those in control group（P〈0.05）.The conduction velocity of gastrocnemius nerve and tibial nerve of patients with peripheral neuropathy in case group were lower than those in control group,but the conduction velocity of gastrocnemius nerve and tibial nerve of patients without peripheral neuropathy in case group were lower than those in patients without peripheral neuropathy in control group,the differences had statistical significance（P〈0.05）.The levels of Vitamin B12 and folic acid in control group were higher than those in case group,and the levels had positive correlation with peripheral nerve damage degree of patients in case group.The levels of Vitamin B12 and folic acid in patients with peripheral neuropathy in case group were lower than those in people with peripheral neuropathy in control group.Conclusion The levels of Vitamin B12 and folic acid have positive correlation with the damage degree of peripheral neuropathy in patients with Parkinson＇s disease.The lower the levels of folic acid,vitamin B12 are,the greater the likelihood of the occurrence of peripheral neuropathy is and the more severe the disease is.
出处
《中国实用神经疾病杂志》
2016年第11期21-22,共2页
Chinese Journal of Practical Nervous Diseases
关键词
帕金森病
周围神经病变
叶酸
维生素B12
Parkinson＇s disease
Peripheral neuropathy
Folic acid
Vitamin B12
