调控去甲肾上腺素能系统对防治创伤后应激障碍的影响被引量：8

Effect of noradrenergic regulation on prevention and treatment of posttraumatic stress disorder

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摘要个体经历严重创伤性事件后可能会形成创伤后应激障碍(posttraumatic stress disorder,PTSD)。在创伤经历中形成的情绪记忆是以后发展为PTSD的重要病理机制。PTSD的形成涉及到情绪记忆的过度巩固,而去甲肾上腺素能神经信号可增强情绪记忆的巩固和再巩固。因此,在创伤记忆的巩固和再巩固期间阻断去甲肾上腺素能神经信号,而在创伤记忆的消退期间增强去甲肾上腺素能神经信号,可能会破坏和或抑制病理性的情绪记忆,从而预防或治疗PTSD。 Exposure to traumatic experience may result in the development of posttraumatic stress disorder （PTSD）. The formation of emotional memories following exposure to a traumatic event is an important mechanism for the subsequent development of PTSD. Animal and human research suggests that the development of PTSD may involve the overconsolidation of memories of a traumatic experience. Noradrenergic signaling strengthens the consolidation and reconsolidation of emotional memory. Therefore, the enhancement of noradrenergic signaling during extinction may strengthen the consolidation of extinction memory, whereas the disruption of noradrenergic signaling during consolidation and reconsolidation may abolish the pathological emotional component of memories, thus alleviating PTSD.

作者王红波朱湘茹

机构地区河南大学认知与行为研究所

出处《心理科学进展》 CSSCI CSCD 北大核心 2016年第6期923-933,共11页 Advances in Psychological Science

基金国家自然科学基金青年项目"自我启动影响奖赏加工的ERP研究"(31300846)

关键词去甲肾上腺能巩固消退再巩固创伤后应激障碍 noradrenergic consolidation extinction reconsolidation posttraumatic stress disorder

分类号 B845 [哲学宗教—心理学]

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