摘要
目的探讨血清VHL,HIF-1α和HIF-2α的表达水平与肾癌临床病理特征的关系。方法收集肾癌患者43例(肾癌组)和同期健康查体者40例(对照组);检测两组血清VHL,HIF-1α和HIF-2α水平;测定患者癌灶最大直径;对所有患者进行6个月随访。结果与对照组比较,肾癌患者血清VHL水平明显降低,而HIF-1α和HIF-2α水平明显升高(P<0.01);肾癌患者血清VHL、HIF-1α和HIF-2α表达与患者年龄、性别无明显相关(P>0.05),而与病理分级、临床分期、癌灶大小以及淋巴结转移显著相关(P<0.01);所有肾癌患者随访6个月,6例复发,37例未复发,复发组患者术后血清VHL水平明显低于未复发组,而HIF-1α和HIF-2α水平明显高于未复发组,比较差异均有统计学意义(P<0.05,P<0.01)。结论血清VHL,HIF-1α和HIF-2α水平与肾癌病理分级、临床分期、癌灶大小以及淋巴结转移显著相关,提示上述指标可成为判定肾癌发生、发展以及复发的重要指标。
Objective To investigate relationship between expression of serum VHL,HIF-1α and HIF-2α and the clinicopathological features in renal carcinoma. Methods 43 patients with renal cell carcinoma were the renal carcinoma group and40 healthy examinees were the control group. Levels of serum VHL,HIF-1α and HIF-2α in the 2 groups were detected. The maximum diameters of carcinoma foci were detected. Studies are needed with follow up of 6 months to record relapse cases. Relationship between expression of serum VHL,HIF-1α and HIF-2α and the clinicopathological feature in renal carcinoma were analyzed.Results Level of serum VHL in the renal carcinoma group was obviously lower than the control group,while levels of HIF-1αand HIF-2α were obviously higher（ P〈0. 01）. Expression of serum VHL,HIF-1α and HIF-2α was not related to age and sex in renal carcinoma（ P〉0. 05）,while was significantly correlated with pathological grade,clinical stages,size of carcinoma and lymphatic metastasis（ P〈0. 01）. All patients of renal carcinoma were followed up by 6 months with 6 recurrent cases and 37 non-recurrent cases. Level of serum VHL in recurrent cases was obviously lower,while levels of HIF-1α and HIF-2α were obviously higher than non-recurrent cases,there had significant differences（ P〈0. 05,P〈0. 01）. Conclusion Levels of serum VHL,HIF-1α and HIF-2α are correlated significantly with pathological grade,clinical stages,size of carcinoma and lymphatic metastasis,which indicates indexes mentioned above could be important indicators of judging occurrence,development and recurrence of renal carcinoma.
出处
《实用癌症杂志》
2016年第6期895-898,共4页
The Practical Journal of Cancer
