摘要
目的研究肿瘤标记物α-甲胎蛋白（AFP）、甲胎蛋白抑制体（AFP-L3）及脱-γ-羧基-凝血酶原（DCP）对肝细胞癌（HCC）患者行肝切除术后复发的预测价值。方法收集行HCC肿瘤病灶根治性切除术的患者58例,考察患者的基本情况以及血清DCP、AFP及AFP-L3水平与HCC术后复发率的关系。结果术后血清AFP、DCP及AFP-L3水平均升高的患者复发率均明显提高。多因素分析结果显示：HCC患者肝切除术前血清AFP、DCP及AFP-L3联合检测与术后复发率无相关性[1.13（0.804-1.479）,P〉0.05],而术后血清AFP、DCP及AFP-L3联合检测则是影响术后复发率的独立因素[3.68（1.711-3.798）,P〈0.01]。结论血清中肿瘤标记物AFP、DCP及AFP-L3联合检测对HCC患者肝切除术后复发监测敏感有效,为HCC术后疗效评估及追踪复查提供了一条新途径。
Objective To study the predictive value of combined detection of 3 tumor markers（ AFP,AFP-L3 and DCP） for relapse after resection of hepatocellular carcinoma（ HCC）. Methods 58 HCC patients treated with radical resection were collected,and the relationship between serum DCP,AFP and AFP-L3 levels and HCC recurrence rate was detected. Results The postoperative serum AFP,DCP and AFP-L3 levels were elevated and the relapse rate in patients improved significantly. Multivariate analysis showed that joint detection of serum AFP,DCP and AFP-L3 levels before liver resection had no correlation with recurrence rate[1. 13（ 0. 804 - 1. 479）,P〉0. 05]. Joint detection of serum AFP,DCP and AFP-L3 levels after liver resection was an independent factor affecting recurrence rate [3. 68（ 1. 711 - 3. 798）,P〈0. 01]. Conclusion The combined detection of serum tumor markers AFP,DCP and AFP-L3 is highly sensitive and effective in monitoring the recurrence rate of HCC patients after liver resection. It can provide a new way to track and evaluate postoperative efficac.
出处
《实用癌症杂志》
2016年第6期983-985,共3页
The Practical Journal of Cancer
