摘要
目的观察化毒愈肠方与益生菌联合治疗轻中度溃疡性结肠炎(UC)的疗效和安全性。方法选择柳州市中医院2013年6月至2015年6月门诊和住院的轻中度UC患者62例,根据患者意愿分为两组,研究组33例患者于活动期给予化毒愈肠方内服灌肠治疗,症状缓解后化毒愈肠方与益生菌维持治疗;对照组29例患者于活动期给予柳氮磺吡啶肠溶片内服灌肠治疗,症状缓解后柳氮磺吡啶肠溶片维持治疗,疗程结束后评价近期疗效,比较菌群变化;所有患者均随访12个月,比较两组复发率。结果疗程结束后两组症状积分、脾虚湿蕴证积分、活动度评分均较治疗前显著降低(P<0.05)。研究组症状积分、脾虚湿蕴证、活动度积分降低幅度明显大于对照组(P<0.05)。研究组治疗后乳酸杆菌、双歧杆菌数量较治疗前增加,大肠杆菌、肠球菌较治疗前减少(P<0.05)。对照组治疗前后菌群无明显变化。研究组完全缓解率为45.45%,总有效率为100%,随访12个月复发率为42.42%;完全缓解率和总有效率明显高于对照组,复发率显著低于对照组(P<0.05)。研究组无明显不良反应病例,两组不良反应发生情况比较差异有统计学意义(P<0.05)。结论化毒愈肠方与益生菌联合治疗UC安全性好,可改善患者临床症状,维持肠道菌群平衡,从而提高疗效,减少复发。
Objective To observe the therapeutic effect and safety of Huadu yuchang prescription combined with probiotics in treatment of patients with mild-moderate ulcerative colitis（UC）. Methods Sixty-two patients with mild-moderate UC from June 2013 to June 2015 were selected and randomly divided into two groups, 33 patients in study group were given Huadu yuchang prescription oral administration and enema treatment, and maintenance treatment with Huadu yuchang prescription combined with probiotics after symptomatic relief. Twenty-nine patients in control group were given sulfasalazine eolonosoluble capsules oral ad- ministration and enema treatment, and maintenance treatment with sulfasalazine colonosoluble capsules after symptomatic relief. The short-term efficacy after treatment were evaluated and the flora changes were compared. All patients were followed up for 12 months, the recurrence rate of the two groups was compared. Results After the end of treatment, the symptoms score and activ- ity score of the two groups were significantly decreased than before treatment（ P 〈 0. 05 ）, and those of study group were signifi- cantly decreased than those of control group （ P 〈 0. 05 ）. After treatment, the number of lactobacillus and lactobacillus in the study group was increased compared with that before treatment, and Escherichia coli and nterococcus were decreased （P 〈 0.05）. There was no obvious change in the control group before and after treatment. In the study group, the complete remission rate was 45.45% , the total effective rate was 100% , the recurrence rate of 12 months follow up was 42. 42% , the total response rate and the total effective rate was significantly higher than that in the control group （ P 〈 0. 05 ）. There was no obvious adverse reaction in the study group, the difference of adverse reactions between the two groups was significant （P 〈 0. 05 ）. Conclusion The safety of Huadu yuchang prescription combined with probiotics in treatment of patients with mild-moderate UC is high, it can improve the clinical symptoms, maintain the balance of intestinal bacteria, so as to improve the curative effect and reduce the recurrence.
出处
《临床医学》
CAS
2016年第5期111-114,共4页
Clinical Medicine
关键词
化毒愈肠方
益生菌
轻中度溃疡性结肠炎
疗效
安全性
Huadu yuchang prescription
Probiotics
Mild-moderate ulcerative colitis
Efficacy
Safety
