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Hippo通路调控细胞增殖与凋亡的研究进展 被引量：2

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摘要 经过科学家20多年的研究发现,Hippo信号通路对促进组织生长、调节器官大小起着重要的作用。该通路广泛存在于生命体中,且通过转录因子TAZ/YAP来发挥其重要的生物学功能,而TAZ/YAP又受到应力信号及G-蛋白偶联受体调节因子(GPCRs)的调节。近来有研究表明,在胚胎干细胞(ESCs)中Hippo通路也起到了关键性作用。作者将对TAZ/YAP的具体调控机制作一综述。
作者 毛幸 周晓明 吴小涛 洪鑫
机构地区 东南大学医学院 东南大学附属中大医院脊柱外科
出处 《东南大学学报（医学版）》 CAS 北大核心 2016年第3期413-417,共5页 Journal of Southeast University(Medical Science Edition)
基金 国家自然科学基金资助项目(81572170)
关键词 Hippo信号通路 TAZ/YAP G-蛋白偶联受体调节因子 胚胎干细胞 综述
分类号 R329.25 [医药卫生—人体解剖和组织胚胎学]
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参考文献44

  • 1周洲,朱金水.Hippo通路及YAP基因研究的新进展[J].现代肿瘤医学,2011,19(6):1241-1244. 被引量：10
  • 2YU F X,ZHAO B,PANUPINTHU N,et al.Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling[J].Cell,2012,150(4):780-791.
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二级参考文献60

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东南大学学报（医学版）
2016年 第3期

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