摘要
目的探究Ki-67抗原与细胞周期依赖性蛋白激酶8(CDK8)在宫颈癌和宫颈上皮内瘤变中的表达和临床意义。方法选取宫颈癌患者64例,宫颈上皮内瘤变(CIN)患者138例,并对其进行分级分期,同时选取正常妇女宫颈组织50例,运用免疫组化方法检测所纳入研究病例宫颈组织Ki-67抗原与CDK8的表达水平。结果Ki-67与CDK8在正常宫颈、宫颈癌、CIN中的阳性率比较,差异均有统计学意义(P﹤0.05);Ki-67与CDK8在宫颈癌各分化程度间,各临床分期间的阳性率比较,差异均有统计学意义(P﹤0.05);Ki-67与CDK8在鳞癌中的阳性率与腺癌比较,及在有无淋巴结转移宫颈癌中的阳性率比较,差异均有统计学意义(P﹤0.05)。结论 Ki-67抗原及CDK8与宫颈癌、CIN的病变程度存在一定的关系,检测其表达水平和强弱可能有助于预测宫颈高度病变的转归。
Objective To explore the expression and clinical significance of Ki-67 antigen and CDK8 in cervical cancer and cervical intraepithelial neoplasia. Method A total of 64 cases of cervical cancer, and 138 cases of cervical intraepithelial neoplasia, were enrolled in this study, of which the differentiation and stage were determined;meanwhile, 50 cases of normal cervical tissues were included as control, and immunohistochemical method was applied to detect the expression level of Ki-67 antigen and CDK8 in these tissues. Result The positive rates of Ki-67 and CDK8 in normal cervix, cervical cancer and cervical intraepithelial neoplasia were significantly different （P〈0.05）; the positive rates of Ki-67 and CDK8 varied significantly with the differentiation, and clinical stages of cervical cancer （P〈0.05）; And the positive rates in squamous carcinoma vs adenocarcinoma, and in the presence of lymph node metastasis vs no metastasis were of statistically significant difference （P〈0.05）. Conclusion Ki-67 antigen and CDK8 are generally associated with the stage of cervical cancer and cervical intraepithelial neoplasia, besides, the expression level and potential might be useful in predicting the outcome of cervical cancer in advanced stage.
出处
《癌症进展》
2016年第4期350-352,356,共4页
Oncology Progress
