摘要
目的探讨骨外间叶性软骨肉瘤(MC)的临床病理、免疫表型及鉴别诊断。方法对2例MC进行组织病理学及免疫组化观察。结果 2例MC分别位于胰腺和肺。临床表现主要为腹痛和咳嗽、气短。影像学表现为边缘清晰的高密度肿瘤。组织学显示肿瘤由原始未分化小细胞和分化较成熟的透明软骨小岛构成。免疫组化显示未分化小细胞胞膜CD99呈不同程度(+),vimentin(+);软骨S-100蛋白(+)。结论 MC是一种少见的高度恶性肿瘤,结合组织病理形态特征及免疫组化染色对诊断有帮助。
Objective To investigate the clinicopathological and immunohistochemical features of extrskeletal mesenchymal chondrosarcoma and its differential diagnosis.Methods Two cases of extrskeletal mesenchymal chondrosarcoma were studied with histopathological observation and immunohistochemical staining. Results The tumors located at pancreas and lung,clinical features were abdominal pain and cough. Enhanced CT scan revealed sharp-edged high intensity tumors. Microscopically, the tumors were composed of the primitive undifferentiated cells and welldifferentiated hyaline cartilage islets. Immunohistochemically,the primitive undifferentiated cells were positive for CD99 and Vim,the cartilage islets were positive for S-100. Conclusions Mesenchymal chondrosarcoma is a rare and highly malignant tumor;its histopathological features and immunohistochemicalstaining help make a definite diagnosis.
出处
《诊断病理学杂志》
CSCD
2016年第6期420-422,427,共4页
Chinese Journal of Diagnostic Pathology
关键词
间叶性软骨肉瘤
诊断
鉴别诊断
Mesenchymal chondrosarcoma
Diagnosis
Differential diagnosis
