摘要
目的 观察三仁汤加减治疗湿热内蕴型功能性消化不良的临床效果。方法 选取2014年1月～2015年5月四川省宜宾市第二人民医院收治的湿热内蕴型功能性消化不良患者94例作为研究对象,并采用随机数字表法将其随机分为两组,观察组和对照组,每组各47例。对照组患者给予枸橼酸莫沙必利片口服治疗,5 mg/次,3次/d;观察组患者给予三仁汤加减治疗,每日1剂。两组患者均以2周为1个疗程。观察比较两组治疗前后胃脘痞满、纳呆、恶心呕吐、口苦或黏、肢体困重、大便溏稀等中医主要证候积分,并评价中医证候疗效,记录两组治疗前后促胃动素、促胃液素水平,分析安全性。结果 治疗后两组胃脘痞满、纳呆、恶心呕吐、口苦或黏、肢体困重、大便溏稀等中医主要证候积分均较治疗前显著降低（P〈0.05）,且观察组治疗后胃脘痞满、恶心呕吐积分低于对照组（P〈0.05）,其余证候积分组间差异无统计学意义（P〉0.05）。治疗后观察组总有效率（91.49%）高于对照组（85.11%）,但差异无统计学意义（P〉0.05）。治疗后观察组和对照组促胃动素、促胃液素水平[（299.73±65.24）、（70.38±9.46）ng/L;（284.29±55.47）、（73.75±13.66）ng/L]均较治疗前[（223.15±39.41）、（25.79±4.77）ng/L;（211.35±36.68）、（23.38±5.32）ng/L]显著提高,差异有统计学意义（P〈0.05）,但两组治疗后组间差异无统计学意义（P〉0.05）。治疗过程中两组患者均无严重不良反应出现。结论 三仁汤加味治疗湿热内蕴型功能性消化不良效果良好,能明显缓解临床症状,改善促胃动素、促胃液素水平,且无明显不良反应,值得临床推广应用。
Objective TO observe the clinical effect of modified Sanren Decoction in the treatment of internal retention of damp-heat type of functional dyspepsia. Methods Ninety four cases of patients with internal retention of damp-heat type of functional dyspepsia admitted to Yibin Second People＇s Hospital from January 2014 to May 2015 were selected as research objects, and they were divided into two groups according to random number table： observation group and control group, with 47 cases in each group. The control group was given Mosapride Citrate Tablets orally, once 5 mg, three times a day; the observation group was given modified Sanren Decoction, one dose a day, 2 weeks were as a course. The scores of main syndromes of traditional Chinese medicine including stomach fullness, anorexia, nausea and vomiting, bitter or sticky mouth, heavy body, loose stool before and after treatment of the two groups were observed and compared, and the effect of the two groups was evaluated, the levels of motilin and gastrin before and after treatment of the two groups were recorded, and the safety was analyzed. Results After treatment, the scores of main syndromes of traditional Chinese medicine including stomach fullness, anorexia, nausea and vomiting, bitter or sticky mouth, heavy body, loose stool before and after treatment of the two groups were all significantly decreased compared with before treatment （P 〈 0.05）, and the scores of stomach fullness, nausea and vomiting in the observation group were lower than those of control group （P 〈 0.05）, the left scores between the two groups had no statistically significant differences （P 〉 0.05）. After treatment, the total effective rate of observation group （91.49%） was higher than that of control group （85.11%）, while the difference was not statistically significant （P 〉 0.05）. After treatment, the levels of motilin and gastrin in the observation group and control group [（299.73±65.24）, （70.38±9.46） ng/L; （284.29±55.47）, （73.75±13.66） ng/L] were all higher than those before treatment [（223.15±39.41）, （25.79±4.77） ng/L; （211.35±36.68）, （23.38±5.32） ng/L], the differences were statistically significant （P 〈 0.05）, while there were no statistically significant differences after treatment between the two groups （P 〉 0.05）. There were no serious adverse reactions of the two groups during the treatment. Conclusion Modified Sanren Decoction in the treatment of internal retention of damp-heat type of functional dyspepsia has good clinical effect, which can significantly relieve clinical symptoms, improve the levels of motilin and gastrin, without significant adverse reactions, which is worthy of clinical promotion and application.
出处
《中国医药导报》
CAS
2016年第16期112-115,共4页
China Medical Herald
关键词
三仁汤
功能性消化不良
湿热内蕴
临床效果
Sanren Decoction
Functional dyspepsia
Internal retention of damp-heat
Clinical effect
