摘要
目的探讨比卡鲁胺联合戈舍瑞林间歇性治疗对局部晚期前列腺癌的疗效和局部晚期前列腺癌患者的护理要点。方法选择医院2012年6月至2014年6月收治的前列腺癌晚期患者146例,随机分为对照组及观察组,各73例。对照组给予比卡鲁胺(口服,每次50 mg,每日1次)并联合戈舍瑞林(注射,每次3.6 mg,1次/4周)持续治疗。观察组予比卡鲁胺联合戈舍瑞林间歇性治疗,两组均配合相同护理措施。观察并记录两组患者在治疗前和治疗后1,6,12个月时的血清前列腺特异性抗原(PSA)、游离(f-PSA)的变化,排尿梗阻症状及骨转移灶改善情况。统计两组患者的治疗费用,并记录治疗期间不良反应发生的情况。结果与治疗前相比,两组患者情况均有明显改善,肿瘤标志物血清PSA及f-PSA值均显著下降,有自觉排尿梗阻症状及骨转移灶患者人数显著减少,差异均具有统计学意义(P<0.05),但组间比较无统计学意义(P>0.05)。观察组平均治疗费用明显低于对照组(P<0.05)。两组主要不良反应为性功能障碍、潮热等,观察组发生率远低于对照组(P<0.05)。结论比卡鲁胺联合戈舍瑞林间歇性治疗局部晚期前列腺癌的疗效与持续性治疗相同,同时配合护理措施更能有效缓解患者临床症状,但间歇性治疗可显著减少患者的医疗费用,且不良反应少,安全性更高,值得临床推广。
Objective To observe the efficacy of intermittent treatment of bicalutamide combined with goserelin for locally advanced prostate cancer, and to investigate its nursing points. Methods 146 cases with advanced prostate cancer from June 2012 to June 2014 were randomly divided into the control group and the observation group, 73 cases in each group. The control group was given bicalu- tamide（oral, 50 mg/time, qd） combined with goserelin （injection, 3.6 mg/time, 1 time/4 weeks） ） continuous treatment; the observation group was given bicalutamide combined with goserelin intermittent treatment; both groups were given the same nursing measures. The changes of serum PSA and f-PSA before treatment and at 1, 6, 12 months after treatment, as well as the improvement of obstructive voiding symptoms and bone metastases of the two groups were observed and recorded. The cost of the treatment in the two groups was statistically recorded, and the adverse reactions during treatment were recorded. Results Compared with before treatment, both groups showed significant improvement, tumor markers in serum PSA and f-PSA values decreased significantly, and there was a significant reduction in the number of symptoms and bladder obstructive voiding and bone metastases（ P 〈 0. 05）, but without statistically signifi- cant difference between the two groups（ P 〉 0.05）. The average cost of treatment in the observation group was significantly lower than the control group（ P 〈 0. 05）. The main adverse reactions occurred in the two groups were sexual dysfunction, fever, etc. The main ad- verse reactions occurred in the observation group was much fewer than the control group（ P 〈 0.05）. Conclusion The application of bicalutamide combined with goserelin intermittent treatment for locally advanced prostate cancer has the same efficacy with the continu- ous treatment. With more effective nursing measures, it can alleviate the clinical symptoms. But intermittent treatment can significantly re- duce the patient＇s medical cost with fewer adverse reactions and higher safety, which is worthy of clinical promotion.
出处
《中国药业》
CAS
2016年第11期46-48,共3页
China Pharmaceuticals
关键词
比卡鲁胺
戈舍瑞林
前列腺癌
临床观察
护理干预
bicalutamide
goserelin
prostate cancer
clinical observation
nursing intervention
