摘要
目的探讨乌鲁木齐地区碘营养状态与甲状腺癌的关系。方法选取2014年3—12月在新疆医科大学第一附属医院血管甲状腺外科行手术治疗并经病理证实的甲状腺良性结节患者158例为甲状腺良性结节组、甲状腺癌患者156例为甲状腺癌组,及同期在新疆医科大学第二附属医院体检中心行甲状腺超声检查示甲状腺形态正常者301例为甲状腺形态正常组。记录3组一般资料、尿碘、甲状腺功能和甲状腺自身抗体表达水平,并进行比较分析。甲状腺癌危险因素分析采用多因素Logistic回归分析。结果 3组性别、年龄间差异有统计学意义(P<0.05);而民族间差异无统计学意义(P>0.05)。3组血清总三碘甲状腺原氨酸(TT3)、总甲状腺素(TT4)、促甲状腺激素(TSH)、甲状腺球蛋白抗体(Tg Ab)、甲状腺过氧化物酶抗体(TPOAb)水平间差异均有统计学意义(P<0.05)。615例受试者尿碘水平为261.50(221.50)μg/L,其中甲状腺形态正常组为257.60(169.35)μg/L,甲状腺良性结节组为261.05(263.42)μg/L,甲状腺癌组为297.90(374.40)μg/L,3组间差异有统计学意义(P<0.05);其中甲状腺癌组与甲状腺良性结节组、甲状腺形态正常组比较,甲状腺良性结节组与甲状腺形态正常组比较,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,女性、血清TgAb异常、碘过量是甲状腺癌的危险因素(P<0.05)。结论乌鲁木齐地区人群碘缺乏状态已基本纠正,处于超适宜量水平,女性、血清TgAb异常、碘过量是甲状腺癌的危险因素,建议该地区人群饮食上控制含碘食物及碘盐的摄入。
Objective To study the correlation between iodine nutritional status and thyroid cancer of people in Urumqi. Methods We recruited 158 patients who were confirmed with benign thyroid nodules and 156 patients who were confirmed with thyroid cancer after surgery and pathological confirmation in the First Affiliated Hospital of Xinjiang Medical University from March to December 2014 as benign thyroid nodule group and thyroid cancer group respectively. We also enrolled301 patients who were confirmed with normal thyroid gland form by thyroid ultrasound in the physical examination center in the Second Affiliated Hospital of Xinjiang Medical University in the same period. The general data,urine iodine,thyroid function and thyroid autoantibody expression of the three groups were recorded and compared. Risk factors for thyroid cancer were investigated by multivariate Logistic regression analysis. Results The three groups were significantly different in gender and age（ P〈0. 05）,but were not significantly different in ethnic group（ P〈0. 05）. The three groups were significantly different in the levels of TT3,TT4,TSH,Tg Ab and TPOAb（ P〈0. 05）. The average urine iodine level of the 615 subjects was 261. 50（ 221. 50） μg/L,with 257. 60（ 169. 35） μg / L for normal thyroid gland form group,261. 05（ 263. 42） μg / L for benign thyroid nodule group and 297. 90（ 374. 40） μg / L for thyroid cancer group; the differences among the three groups were significant（ P〈0. 05）,with thyroid cancer group significantly different from benign thyroid nodule group and normal thyroid gland form group and benign thyroid nodule group significantly different from normal thyroid gland form group（ P〈0. 05）. Multivariate Logistic regression analysis showed that females,abnormal serum Tg Ab level and excessive iodine intake were risk factors for thyroid cancer（ P〈0. 05）. Conclusion The iodine deficiency among the population in Urumqi has been substantially corrected and has surpassed appropriate quantity. Females,abnormal serum Tg Ab level and excessive iodine intakeare risk factors for thyroid cancer,so we recommend the intake of food containing iodine and iodised salt be controlled in the diet of people in Urumqi.
出处
《中国全科医学》
CAS
CSCD
北大核心
2016年第16期1907-1910,共4页
Chinese General Practice
基金
新疆维吾尔自治区自然科学基金资助项目(2013211A057)--乌鲁木齐地区碘和硒营养状态与甲状腺癌的相关性研究
