摘要
目的探讨匹多莫得辅助治疗对婴幼儿支原体肺炎患儿的T淋巴细胞亚群的百分比的影响及细胞因子和免疫球蛋白表达的变化。方法选取100例婴幼儿支原体肺炎患儿,随机分为观察组(n=50)和对照组(n=50)。对照组给予红霉素治疗,观察组采用红霉素联合匹多莫德治疗,比较两组患儿T淋巴细胞亚群、血清细胞因子、血清免疫球蛋白及临床疗效。结果与对照组比较,观察组患儿外周血中CD3+、CD4+和CD4+/CD8+细胞数显著升高,而CD8+细胞数则显著下降,两组间比较,其差异有显著性(P<0.05);观察组患儿血清中白细胞介素(IL)-12、IFN-γ的水平显著升高,而IL-6和IL-8的水平则明显下降(P<0.05);此外,观察组患儿血清Ig M、Ig G和Ig A的水平较对照组增高(P<0.05),并且观察组的临床疗效要优于对照组(92.0%vs 66.0%,P<0.05)。结论匹多莫得佐治婴幼儿支原体肺炎,可显著改善患儿免疫功能,提高临床疗效,值得临床推广使用。
Objective To evaluate the effect of pidotimod on T cell subpopulations, cytokines and immune globulin in infantile Myeoplasma pneumonia. Methods 100 infantile Mycoplasma pneumonia were randomly divided into control group （n = 50） and observation group （n = 50）.Pidotimod combined with erythromycin were used in observation group and erythromycin alone was used in control group.The T cell subpopulations, serum cytokines, serum immune globulin and clinical efficacy were compared between the two groups. Results After treatment, the CD3^＋, CD4^＋, CD4^＋/CD8^＋ of observation group significantly increased, and CD8^＋ were significantly reduced, statistically significant difference compared with control group（P〈0.05） .The observation group serum IL-12, IFN-γ significantly increased, and IL-6, IL-8 were signifi- cantly reduced, statistically significant difference compared with control group （P〈0.05）.The levels of IgM, IgG and IgA in observation group were significantly increased,statistically significant difference compared with control group（P〈0.05）.The clinical efficacy of observation group was better than control group （92.0% vs 66.0%）, showed significant differences between the two groups（P〈0.05）. Conclusion Using pidotimod treatment infantile Mycoplasma pneumonia can improve immune function, enhance curative effect, worth clinical promotion.
出处
《中南医学科学杂志》
CAS
2016年第3期299-302,共4页
Medical Science Journal of Central South China
