摘要
目的 探讨持续呼吸末正压给氧治疗婴幼儿毛细支气管炎的有效性、安全性。方法 将2015年1-12月在本院儿科重症监护室确诊为毛细支气管炎的病人160例回顾性分为对照组与治疗组,每组80例,对照组予持续低流量吸氧,治疗组予持续呼吸末正压给氧辅助通气。分析两组治疗后6、24 h呼吸（R）、心率（HR）及血氧饱和度（SO_2）、动脉血氧分压（PaO_2）、动脉血二氧化碳分压（PaCO_2）、血清乳酸浓度（Lac）等血气值。治疗4天后,比较两组疗效,观察并记录两组喘憋、咳嗽以及肺部湿啰音等主要临床症状消失时间。结果 在治疗后6、24h,治疗组R、HR、PaCO_2、Lac较对照组降低（P〈0.05或0.01）,SO_2、PaO_2较对照组升高（P〈0.05或0.01）。治疗4天后,治疗组总有效率明显高于对照组（P〈0.05）。与对照组比较,治疗组喘憋、咳嗽与肺部湿啰音消失时间缩短（P〈0.05）。结论 采用持续呼吸末正压辅助通气治疗婴幼儿毛细支气管炎可以提高疗效,缩短疗程,改善愈后。
Objective To explore the efficacy and safety of positive end expiratory pressure in the treatment of chil- dren patients with capillary bronchitis. Methods One hundred and sixty children patients with capillary bronchitis in the pediatric intensive care unit （ICU） of our hospital from January 2015 to December 2015 were collected,and then were di- vided randomly into 2 groups： treatment group （n= 80） and control group （n= 80）.Children patients in control group ac- cepted continuous low flow oxygen therapy, whereas those in treatment group were treated with positive end expiratory pres- sure.Respiration （R）, heart rate （HR）, blood oxygen saturation（ SO_2 ）, partial pressure of oxygen in artery （PaO_2 ）, partial pressure of carbon dioxide in artery （ PaCO_2 ） , and serum lactic acid （Lac） concentration were analyzed at 6 and 24 hours after treatment. On day 4 posttreatment, curative effect was compared, and the extinction time of wheeze, cough and pulmonary moist rale was observed and recorded. Results In comparison with control group, R, HR, PaCO_2 and Lac were significantly decreased but SO2 and PaO2 were significantly increased at 6 and 24 hours after therapy in treatment group （P〈0.05 or 0.01 ）.The total effective rate on day 4 posttreatment was higher in treatment group than that in control group （P〈0.05） .The extinction time of wheeze, cough and pulmonary moist rale was significantly reduced in treatment group compared with control group （P〈0.05）. Conclusion Positive end expiratory pressure treatment can enhance curative effect, shorten course of treatment and improve prognosis in children patients with capillary bronchitis.
出处
《中南医学科学杂志》
CAS
2016年第3期332-334,共3页
Medical Science Journal of Central South China
关键词
持续呼吸末正压给氧
毛细支气管炎
血气分析
positive end expiratory pressure
capillary bronchitis
blood gas analysis
