摘要
目的研究乳腺癌患者血清中的Six1(sine oculis homeobox homolog 1)水平,探讨其与乳腺癌临床病理特征的关系。方法应用酶联免疫吸附试验(ELISA)方法检测原发性乳腺癌患者(60例)、乳腺良性疾病患者(45例)和正常对照者(20例)的血清Six1水平。结果乳腺癌患者血清中Six1水平明显高于乳腺良性疾病患者及正常对照者,且乳腺良性疾病患者血清Six1水平也高于正常对照者(P<0.05)。乳腺癌患者血清中Six1高水平与肿瘤TNM分期、组织学分级以及淋巴结转移有关(P<0.05),与年龄、肿瘤直径无关(P>0.05)。结论 Six1与乳腺癌的发生及其侵袭转移具有相关性,其变化在乳腺癌的转移和预后评测中起重要作用。
Objective To investigate the level of serum Sine oculis homeobox homolog 1 （Six1） in breast cancer patients and analyze the relationship between its expression and the clinical pathological characteristics of breast cancer.Methods The level of serum Six1 was detected in primary breast cancer patients （n =60）,breast benign disease patients （n =45）,normal control subjects （n =20） by ELISA,and the relationship between the level of serum Six1 and clinical pathological characteristics was studied.Results The level of serum Six1 in breast cancer group was higher than that in breast benign disease group and in normal control group In addition,the level of serum Six1 in breast benign disease group was higher than that in normal control group （P ＜ 0.05）.The higher level of serum Six1 in breast cancer patients was positively correlated to TNM staging,histological grade,lymph node metastasis （P ＜ 0.05） and negatively correlated to age and tumor size（P ＞ 0.05）.Conclusion Six1 is closely related to the genesis and development of breast cancer and may contribute to metastasis and prognosis of it.
出处
《医学研究杂志》
2016年第6期94-96,共3页
Journal of Medical Research
基金
国家安全生产监督管理总局科研基金资助项目(201306)
关键词
乳腺癌
Six1
临床病理特征
Breast cancer
Six1
Clinical pathological characteristics
