摘要
目的分析GSTM1缺失基因型与白血病遗传易感性的关系。方法 131例白血病患者纳入病例组,200例体检健康者纳入对照组。采用巢式PCR检测GSTM1、GSTT1基因型。应用χ2检验和精确概率法比较各基因型频率在病例组与对照组之间的差异,用比值比（OR）及其95%的可信区间（CI）表示各基因型发生白血病的风险度。结果病例组GSTM1缺失基因型频率与对照组比较,差异有统计学意义（P=0.000 1,其OR值为2.152,95%CI为2.301~5.985）;在病例组与对照组中均未检测到GSTT1缺失基因型;CML、AML与ALL组间进行GSTM1缺失基因型频率比较,差异无统计学意义（P〉0.05）。结论GSTM1缺失基因型可能是白血病的重要危险因素。
Objective To investigate the relationship between leukemia susceptibility and gene polymorphism of GSTM1,GSTT1.Methods A total of 131 leukemia patients were recruited into group of patients,and 200 healthy person were recruited into control group.GSTM1 and GSTT1genotypes were determined by multiplex polymerase chain reaction.Chi-square test and Fisher′s exact test was used to compare the differences between the group of patients and control group.Results GSTM1 null genotype frequency in group of patients was slightly higher than that of the control group（P=0.000 1,OR=2.152,95%CI=2.301-5.985）,There was no GSTT1 null genotype detected in group of patients and control group.Moreover,GSTM1 null genotype frequency showed a similar trend between CML,AML and ALL.Conclusion GSTM1 null genotype might be a risk factor of leukemia.
出处
《国际检验医学杂志》
CAS
2016年第12期1610-1611,共2页
International Journal of Laboratory Medicine
基金
甘肃省兰州市科技局自然科学基金项目(2011-2-46)
