摘要
群体感应(QS)最初是指一种细菌细胞之间的通讯系统,即细菌通过产生和释放扩散性信号分子来感知细菌群体密的变化,引起特定基因表达,进而协调群体行为以适应环境变化。大量研究表明,群体感应系统控制细菌多种生理行为,如生物膜的形成、毒素基因的表达、生物发光等。近年的研究表明,真菌中也存在类似于细菌群体感应信号分子的调节分子,该调节分子介导着真菌某些生理行为的调节,如菌相转化、霉菌毒素产生、孢子形成等生理行为。本文从细菌群体感应信号分子和群体感应系统的分类及不同真菌中群体感应现象等方面对近年来群体感应的研究进展进行综述,并探讨霉菌群体感应在霉菌毒素研究中的应用。
Quorum sensing（ QS） originally refers to a cell- to- cell communication mechanism in bacteria mediated by small diffusible signal molecules that trigger changes in a set of gene expression in a population- dependent manner to coordinate collective behavior in response to environmental challenges. Bacteria use quorum sensing communication circuits to regulate a diverse array of physiological activities,such as biofilm formation,bioluminescence,virulence and sporulation. Recent studies have found that among fungi also exist regulatory molecules similar to bacterial quorum sensing signal molecules,and participate in regulation of their physiological behaviors such as phase diversion,pathogenesis,secondary metabolite production etc. The classification of signal molecules and quorum sensing system in bacteria and quorum sensing phenomenon in fungi were reviewed in this paper. The prospect of the quorum sensing research in filamentous fungi was also discussed,So as to provide reference for quorum sensing of mold application research.
出处
《延安大学学报（自然科学版）》
2016年第2期39-44,共6页
Journal of Yan'an University：Natural Science Edition
基金
国家"863"计划项目(2012AA101609-7)
关键词
群体感应
信号分子
霉菌毒素
quorum sensing
signal molecular
mycotoxins
