摘要
目的：探讨新疆维吾尔族、汉族老年人轻度认知功能障碍（MCI）与血浆同型半胱氨酸（Hcy）水平之间的关联。方法采用分层随机多级整群抽样方式，根据美国精神病学会的精神障碍诊断和统计手册第4版修订版（DSM- IV）中 MCI 的临床诊断标准，随机抽取新疆南疆、东疆、北疆等区域，年龄大于等于60岁的维、汉两民族老年人5398例进行 MCI 的流行病学调查。在此基础上采用病例-对照研究方法，从已诊断为 MCI 的患者中选取资料完整的314例作为 MCI 组（维吾尔族161例，汉族153例），同时选取对照组299例（维吾尔族149例，汉族150例），应用酶联免疫法检测两组血浆 Hcy 浓度，比较之间的差异。结果整群MCI 组血浆 Hcy 水平[（17．11±9．17）μmol／L]高于对照组[（12．65±4．57）μmol／L]（P ＜0．05）；其中维吾尔族 MCI 组[（17．23±8．31）μmol／L]、汉族 MCI 组[（16．99±10．28）μmol／L]血浆 Hcy 水平均分别高于其对照组（P ＜0．01）；在不同年龄段中，整群 MCI 组血浆 Hcy 水平60-69岁：（16．99±8．62）μmol／L；70-79岁：（19．73±10．5）μmol／L；≥80岁：（20．97±6．03）μmol／L，均高于对照组（P ＜0．05），且随着年龄的增长，血浆Hcy 水平逐渐增高（P ＜0．05）；男性 MCI 组[（15．34±8．64）μmol／L]及女性 MCI 组[（14．58±6．58）μmol／L]血浆 Hcy 水平均高于对照组（P ＜0．05）。结论血浆 Hcy 水平与新疆老年人 MCI 的发病相关，且其随着年龄增长而升高，高 Hcy 血症是新疆老年人 MCI 发病的危险因素之一。
Objective To explore the association between mild cognitive impairment and plasma homocys-teine of Uygurs and hans aged in Xinjiang.Methods A total of 5398 Uygurs and Hans aged 60 years or older were surveyed in south,east and north of Xinjiang by divided-levels,random,cluster sampling approaches a ccording to the DSM-IV（Diagnostic and Statistical Manual of Mental Disorders,forth version）.Based on the epidemiological investiga-tion,the case-control anlaysis had been adopted.We selected 314 patients with MCI as MCI group （161 Uygurs,153 Hans）and 299 normal elderly people as control group （149 Uighurs,150 Hans）;plasma homocysteine of two groups were compared.Results Plasma homocysteine of MCI group was significant higher than that in the control group （P 〈0.05）,and the result was same in Uygurs and Hans respectively（P 〈0.01）.Plasma homocysteine of MCI group was higher than the control group in different ages （P 〈0.05）,and the homocysteine was gradually increased with age （P 〈0.05 ）.Plasma homocysteine of male and female in MCI group was higher than that in control group （P 〈0.05）.Conclusion Plasma homocysteine relates with the pathogenesis in aged with MCI in Xinjiang ,and increased with age.High plasma homocysteine is an independent risk factor of aged with MCI in Xinjiang,China.
出处
《中国临床保健杂志》
CAS
2016年第4期343-345,共3页
Chinese Journal of Clinical Healthcare
基金
国家自然科学基金资助项目(30960402)
关键词
轻度认知障碍
半胱氨酸
维吾尔族
汉族
危险因素
Mild cognitive impairment
Cysteine
Uygur nationality
Han nationality
Risk factors
