摘要
目的探讨羟考酮联合舒芬太尼用于腹部手术术后患者的镇痛效果。方法选取2013年1月至2016年2月在医院择期行腹部手术患者80例,按随机数字表法分为对照组与观察组,各40例。术后对照组患者应用舒芬太尼镇痛,观察组患者在此基础上加用羟考酮。观察并比较两组患者不同时间点疼痛视觉模拟评分法(VAS)评分、Ramsay镇静评分及术后48 h内自控镇痛按压次数、补救镇痛药物使用情况。结果观察组术后6 h(T_1),12 h(T_2),24 h(T_3)时VAS评分分别为(1.90±0.50)分,(1.80±0.40)分,(1.70±0.40)分,分别低于对照组的(3.00±0.80)分,(2.80±0.70)分,(2.00±0.50)分;术后48 h内自控镇痛按压(2.10±0.60)次,补救镇痛药物使用率为5.00%,分别低于对照组的(5.50±1.30)次,20.00%;观察组T_1,T_2,T_3时Ramsay镇静评分分别为(2.90±0.72)分,(3.30±0.81)分,(2.60±0.62)分,分别高于对照组的(2.50±0.63)分,(2.60±0.61)分,(2.10±0.51)分,差异均有统计学意义(P<0.05)。结论羟考酮联合舒芬太尼用于腹部手术术后患者镇痛效果更明显,在有效提高患者术后镇静程度的同时,还能有效降低相关镇痛药物用量,显著改善患者预后,值得临床推广。
Objective To explore the analgesic effect of oxycodone combined with sufentanil after abdominal surgery. Methods 80 cases of abdominal surgery patients from January 2013 to February 2016 in the hospital were selected and divided into the control group and the observation group according to random number table method, 40 cases in each group. After operation, the control group was given sufentanil analgesia, and the observation group was added with oxycodone on the basis of the control group. The VAS scores different time points, Ramsay scores and 48 h postoperative patient- controlled analgesia pressing times,rescue analgesic drug usage of the two groups were observed and compared. Results VAS scores of post operation 6 h（T1）, 12 h（T2） and 24 h（T3）of the observation group were（ 1.90±0. 50） points, （ 1.80 ±0. 40） points, （ 1.70 ± 0. 40） points, which were respectively lower than （3.00 ±0. 80） points, （2.80 ± 0.70）points, （2. 00 ± 0. 50）points of the control group;48 h postoperative analgesia pressing was （2. 10± 0. 60） times,remedial analgesic drug usage rate was 5.00% ,which were significantly lower than（5.50 ± 1.30）times and 20.00% of the control group;Ramsay score at T1, T2, T3 of the observation were（2.90± 0. 72）points, （3.30± 0. 81 ）points, （2.60 ±0. 62 ） points of the observation group, which were re- spectively higher than（2. 50 ± 0. 63 ） points , （2.60 ± 0. 61 ）points, （2. 10± 0. 51 ）points of the control group, and the differences were sta- tistically significant（ P 〈 0.05）. Conclusion Oxycodone combined with sufentanil for analgesia of patients with abdominal surgery has more obvious postoperative effect, can effectively reduce the usage of analgesic drugs while improving the level of sedation, and signifi- cantly improve the prognosis of patients, which is worthy of clinical promotion.
出处
《中国药业》
CAS
2016年第12期43-45,共3页
China Pharmaceuticals
关键词
羟考酮
舒芬太尼
腹部手术
术后镇痛
oxycodone
sufentanil
abdominal surgery
postoperative analgesia
