摘要
背景:癌症患者术后放疗可能对种植体固位产生不利影响。目的:观察^(60)Co放射及微量元素锌对钛种植体固位强度的影响。方法:选择成年雄性家兔36只,双侧胫骨近心端各置入1枚钛种植体,建立钛种植体动物模型,随机分为对照组、补锌组、放疗组和放疗补锌组。补锌组动物肌注10 g/L硫酸锌,4 mg/kg,1次/d;对照组给予相同剂量的生理盐水;放疗组动物种植部位给予45 Gy的^(60)Co照射并肌注生理盐水;放疗补锌组给予^(60)Co照射的同时补锌。分别于术后1,4,12周处死动物,测量并比较各组钛种植体固位强度。结果与结论:1补锌能够使种植体获得更高的固位强度,并且在术后4周达到较高水平;2^(60)Co照射可以显著抑制种植体固位强度,^(60)Co照射后补锌仍可以提升种植体固位强度;3结果提示,放疗术后适量的补锌能够减轻放疗对种植体固位的不利影响。
BACKGROUND： Irradiation therapy in the cancer patients after surgery may have negative effects on implant fixation. OBJECTIVE： To observe the effects of 60Co irradiation and trace element zinc on fixation strengths of titanium implant. METHODS： Thirty-six adult male rabbits were involved. One piece of titanium implant was separately placed into the bilateral proximal tibial heads in rabbits to set up animal models of titanium implants. The animals were randomly divided into control group, zinc supplement group, 60Co irradiation group and 60Co irradiation and zinc supplement group. Zinc sulfate of 10 g/L was administered intramuscularly to animals in the zinc supplement group at the dose of 4 mg/kg once per day, and those in the control group were treated with saline at the same dose. The animals in the 60Co irradiation group received 60Co irradiation at the dose of 45 Gy and saline by intramuscular injection. Those in the 60Co irradiation and zinc supplement group received 60Co irradiation and zinc sulfate. The animals were killed at 1, 4 and 12 weeks after treatment. The fixation strengths were measured and compared among groups. RESULTS AND CONCLUSION： （1） Zinc supplement made the titanium implants have higher fixation strengths, and reach a high level at 4 weeks after surgery. （2） 60Co irradiation significantly inhibited the fixation strengths of the implants. After 60Co radiation, zinc supplement stil could promote fixation strengths of titanium implants. （3） It is indicated that amount of zinc supplement after irradiation therapy can al eviate the negative effects of irradiation on implant fixation.
出处
《中国组织工程研究》
CAS
北大核心
2016年第25期3764-3770,共7页
Chinese Journal of Tissue Engineering Research
