摘要
目的探讨卡介菌多糖核酸联合咪唑斯汀治疗慢性特发性荨麻疹的治疗效果及安全性。方法纳入我院2013年1月—2014年11月确诊为慢性特发性荨麻疹的患者150例,随机平均分为2组,其中观察组75例,予隔天臀部肌内注射卡介菌多糖酸2 m L并联合每天口服咪唑斯汀10 mg;对照组75例,予每天咪唑斯汀10 mg口服,2组均连续治疗4周。分别于治疗前、治疗后2周、4周及3个月共4个时间点观察2组患者的症状积分的变化情况及有效率,并对2组的不良反应等安全性情况进行分析。结果治疗后2周、4周和3个月2组患者的症状积分和有效率与治疗前比较差异有统计学意义(P<0.05);治疗后2周观察者与对照组症状积分和有效率2组比较差异无统计学意义(P>0.05),而治疗后4周和3个月2组的症状积分和有效率比较差异有统计学意义(P<0.05);2组均未发现严重的不良反应,其中观察组有10例患者、对照组有8例患者出现了轻度的嗜睡现象,观察组、对照组各有2例出现了头痛现象,均未做任何特殊处理,停药后症状消失。所有患者的肝肾功能等实验室检查均无异常表现。结论卡介菌多糖核酸联合咪唑斯汀治疗慢性特发性荨麻疹疗效确切且安全性高。
Objective In order to investigate the efficacy and safety of Bacillus Calmette Guerin-polysaccharide nucleic acid （BCG-PNA） combined with mizolastine in treating chronic idiopathic urticaria. Methods One-hundred and fifty patients diagnosed as chronic idiopathic urticaria in our hospital from January 2013 to November 2014 were randomly divided into two groups. Seventy-five cases in observation group were given intramuscular injection of BCG polysaceharide acid 2 mL every other day combined with taken mizolastine 10 mg orally daily, and 75 cases in control group taken mizolastine 10 mg orally daily, both two groups were treated continuously for 4 weeks. Changes in symptom scores and effective rate of patients in the two groups were observed before treatment, 2 weeks, 4 weeks and 3 months after treatment. Meanwhile adverse reactions and security of the two groups were analyzed. Results After treatment for 2 weeks, 4 weeks and 3 months, the difference of symptom score and effective rate of the patients between the two groups were statistically significant （P〈0.05）. There was no significant difference in symptom scores and effective rate between the two groups and the control group after treatment for 2 weeks （P〉0.05）. And there was a statistically significant difference in symptom scores and effective rate between the two groups after treatment for 4 weeks and 3 months （P〈O.05）. No serious adverse reaction was found in both two groups. Ten patients in observation group and 8 patients in the control group had mild drowsiness phenomenon, and 2 cases in the observation group and 2 cases in the control group had appeared headaches. All of these cases did not do any special treatment, and the symptoms disappeared after withdrawal. All patients with liver and renal function and other laboratory tests showed no abnormal performance. Conclusion BCG-PSN combined with mizolastine in treating chronic idiopathic urticaria have exact curative effect good and high safety.
出处
《中国中西医结合皮肤性病学杂志》
CAS
2016年第3期166-168,共3页
Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine
关键词
卡介菌多糖核酸
咪唑斯汀
联合治疗
慢性特发性荨麻疹
Bacillus Calmette Guerin-polysaccharide nucleic acid
Mizolasline
Combination therapy
Chronic idiopathic urticaria
