摘要
目的观察五色六味方治疗慢性乙型肝炎的疗效及可能作用机制。方法 78例慢性乙型肝炎患者随机分为治疗组和对照组各39例。对照组口服拉米夫定片,每次100mg,每日1次;治疗组在对照组基础上加服五色六味方颗粒剂,每日1剂,两组疗程均为48周。于治疗前及治疗24周、48周时检测患者乙型肝炎病毒(HBV)DNA载量观察阴转率,以及外周血白细胞介素17(IL-17)、FOXP3水平和辅助性T细胞17/调节性T细胞(Th17/Treg)值。结果治疗组治疗24周、48周时HBV DNA阴转率分别为80.77%、92.30%,对照组分别为57.70%、69.23%,治疗组治疗后各时间点HBV DNA阴转率均明显高于对照组(P<0.05)。两组治疗48周时IL-17、FOXP3水平及Th17/Treg值较本组治疗前均有所下降(P<0.05);治疗组治疗24周、48周时IL-17、FOXP3水平及Th17/Treg值均低于同时间点对照组(P<0.05)。结论五色六味方联合拉米夫定片可明显减轻慢性乙型肝炎患者肝脏炎症、增强抗病毒效力,其机理可能与调节Th17/Treg平衡有关。
Objective To examine the effect and possible mechanism of Wuse Liuwei Decoction （五色六味方） treating chronic hepatitis B. Methods Seventy-eigilt patients with chronic hepatitis B were randomized into treatment group and control group, 39 cases in each group. The control group was given lamivudine tablet 100 mg orally each time, once every day. In addition to the treatment of the control group, Wuse Liuwei Decoction granule was given to the treatment group, 1 dose ever）, day. Both groups were treated for 48 weeks. Hepatitis B Virus deoxyribonucleic acid （HBV DNA） load and negative conversion rate, the level of peripheral blood interleukin 17 （IL-17） and fork- head box P3 （FOXP3） , as well as Thl7/Treg of patients was detected before treatment, at the 24th and 48th week of treatment. Results In the treatment group, HBV DNA negative conversion rate at the 24th and 48th week of treatment was 80.77% and 92.30% respectively, while that was 57.70% and 69.23% respectively in the control group. HBV DNA negative conversion rate in the treatment group at all time of treatment was higher than that in the control group （P 〈0.05）. At the 48th week of treatment, the level of IL-17 and FOXP3, as well as Thl7/Treg in both groups decreased compared with those before treatment （P 〈0. 05 ）. At the 24th and 48th week of treatment, the level of IL-17 and FOXP3, as well as Thl7/Treg in the treatment group were lower than those in the control group at the same time （ P 〈 0.05 ）. Conclusion g/use Liuwei Decoction combined with lamivudine tablet might reduce the liver inflammation of patients with chronic hepatitis B and enhance the antiviral effect. The mechanism might relate to regulating Thl7/Treg balance.
出处
《中医杂志》
CSCD
北大核心
2016年第13期1121-1124,共4页
Journal of Traditional Chinese Medicine
基金
国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教发[2014]20号)
国家中医药管理局中医药重点学科建设项目(国中医药人教发[2012]32号)
