摘要
目的 探讨糖皮质激素治疗自身免疫性甲状腺疾病（Autoimmune Thyroid Disease,AITD）的临床效果.方法 将98例自身免疫性甲状腺疾病患者按照数字表法随机分为两组：对照组49例给予常规抗甲状腺药物治疗;观察组49例在对照组基础上给予糖皮质激素治疗;两组疗程均为12周,观察两组临床疗效.结果 观察组总有效率为97.96％,明显高于对照组的59.08％（x2=21.878 8,P＜0.05）;两组治疗后甲状腺过氧化酶抗体（TPOAb）、甲状腺功能检测指标均明显低于治疗前（P＜0.05）,而观察组各项指标均明显低于对照组（P＜0.05）.结论 糖皮质激素治疗自身免疫性甲状腺疾病能够有效控制患者的临床症状与体征,降低其抗甲状腺自身的抗体水平值,是一种比较有效、安全、价廉的治疗方法.
Objective To evaluate the clinical effect of glucocorticoid in the treatment autoimmune thyroid disease （AITD）.Methods In accordance with the digital table method,98 patients with AITD were randomly divided into a control group and an observation group,49 for each group.The control group were given conventional anti-thyroid medication;in addition,the observation group were treated with glucocorticoid.Both groups were treated for 12 weeks.The clinical effect was observed in both groups.Results The total effective rate was 97.96% in the observation group and 59.08% in control group （x 2=21.8788,P〈0.05）.The levels of thyroid peroxidase antibodies （TPOAb） and thyroid function indicators were significantly lower after than before the treatment in both groups （P〈0.05） and in the observation group than in the control group after the treatment （P〈0.05）.Conclusions Glucocorticoid in the treatment of AITD can effectively control the patient＆#39;s clinical symptoms and signs and reduce the level of antithyroid antibody.It is an effective,safe,cheap,treatment method.
出处
《国际医药卫生导报》
2016年第14期2052-2054,共3页
International Medicine and Health Guidance News
