摘要
目的探讨hs-CRP和PCT在新生儿重症细菌感染性疾病预后中的应用价值。方法选择2012年2月-2015年3月本院NICU收治的99例重症细菌感染性疾病患儿为研究对象,选择同一时期进行健康体检的46例新生儿作为对照组,比较患病组和对照组hs-CRP和PCT水平,同时对患病组不同临床转归患者的hs-CRP、PCT、WBC进行动态监测。结果患病组hs-CRP和PCT的水平高于对照组,差异均有统计学意义(P<0.01)。好转组hs-CRP水平、PCT水平及WBC均低于恶化组,差异有统计学意义(P<0.05)。WBC与hs-CRP和PCT均呈正相关(r值分别为0.996 1、0.985 9,P<0.05)。好转组患者hs-CRP和PCT、WBC均持续性下降,恶化组患者hs-CRP和PCT、WBC均持续性升高,差异均有统计学意义(P<0.05)。结论动态监测hs-CRP和PCT的水平对于新生儿重症细菌感染性疾病预后的评估具有重要意义,可用于重症细菌感染性疾病预后判断及病情监测。
Objective To investigate the value of dynamically monitoring hs - CRP and PCT in the prognosis of newborns with severe bacterial infection diseases. Methods 99 newborns with severe bacterial infections treated in NICU of our hospital during February 2012 - March 2015 were selected as the subjects. 46 health newborns for health examination in our hospital during the same period were chosen as the control group. The levels of hs - CRP and PCT in sick group and control group were compared. Meanwhile, dynamic monitoring of hs - CRP, PCT, WBC were carried out based on the clinical outcomes of newborns in sick group. Results The levels of hs - CRP and PCT in sick group were significantly higher than those in the control group, and the difference was statistically significant（ P 〈0.05 ）. WBC score showed positive correlation with hs -CRP and PCT（ r = 0.996 1, 0. 985 9, P 〈 0.05）. hs - CRP, PCT and WBC in improve patients continuously decreased, which in deteriorated group continuously increased. And the difference was statistically significant （ P 〈 0.05 ）. Conclusion Dynamically monitoring the levels of hs - CRP and PCT in the prognosis of newborns with severe bacterial infections have important significance, which could be Used for the prognosis and disease surveillance of severe bacterial infections.
出处
《中国卫生检验杂志》
CAS
2016年第12期1731-1733,共3页
Chinese Journal of Health Laboratory Technology
