摘要
目的研究大面积脑梗死患者不同时期血浆Ghrelin水平的表达及其与同型半胱氨酸(Hcy)的相关性。方法选取42例大面积脑梗死患者(A组)分别于入院后第1、7、14天检测血浆Ghrelin及Hcy水平。另选36例健康体检者作为对照(B组),检测血浆Ghrelin及Hcy水平。结果 1)A组入院后第1、7天的血浆Ghrelin水平较第14天及B组明显下降(P<0.05);第7天较第1天明显下降(P<0.05);第14天与B组间Ghrelin水平的差异无统计学意义(P>0.05)。2)A组入院后第14天、B组中正常Hcy组的Ghrelin水平低于高Hcy组,两组中血浆Ghrelin水平与Hcy水平呈正相关(r=0.420,P<0.05;r=0.591,P<0.05)。结论 1)大面积脑梗死患者血浆Ghrelin水平随病情变化而呈动态变化;2)Ghrelin可能对Hcy引起的血管内膜损伤有保护作用,减缓动脉粥样硬化的发生、发展。
Objective： To investigate the expression of plasma Ghrelin in patiens with large area cerebral infarction at different stages and its correlation with homocysteine. Methods：Forty-two patients with large area cerebral infarction were selected as the case group （A group）, the levels of plasma Ghrelin and blood homocystein were measured at lst,7th,14th days after hospitalization while. 32 cases with health examination were selected as control group （ B group）, the levels of Ghrelin and Hcy were measured. Results ： 1 ） In Group A, the levels of Ghrelin decreased more significantly at 1 st and 7 th days after hospitalization than 14 th days after hospitalization and Group B. The levels of Ghrelin at 7th day after hospi- talization were lower than those at 1 st day. There was no significant difference in the level of Ghrelin between 14th days and Group B. 2） In Group B and at I4th day after hospitalization in Group A, the levels of Ghrelin in normal Hcy group were lower than those in high Hcy group, Ghrelin and Hcy levels were positively correlated （ r = 0. 420, P 〈 0. 05 ; r = 0. 591, P 〈 0. 01 ）. Conclusion： 1 ） The plasma Ghrelin in patients with large area cerebral infarction changes with the development of patient＇ s conditions. 2） Ghrelin may have the protective effect by Hcy intimal injury, slow downing the occurrence and de- velopment of atherosclerosis.
出处
《泰山医学院学报》
CAS
2016年第5期481-483,共3页
Journal of Taishan Medical College
