摘要
【目的】探讨罗库溴铵应用于老年腹腔镜胆囊切除术（LC）患者的麻醉效果。【方法189例拟在本院实施LC手术治疗的患者，随机分为两组，研究组45例和对照组44例，研究组在麻醉中应用罗库溴铵、对照组应用注射用苯磺顺阿曲库铵；观察比较两组麻醉效果的差异。【结果】给药后1min、3min、5min、10min研究组的组胺浓度值、心率（HR）均显著的低于对照组患者（P〈0．05），研究组给药后1min、3rain、5min、10min的平均动脉压（MAP）显著高于对照组（P〈0．05）；研究组患者的肌松起效时间（126．3±9．3）S显著短于对照组（194．5±11．0）s（P〈0．05）、维持时间（49．2±6．9）min显著长于对照组（32．8±6．3）min，且两组相比较差异有显著性（P〈0．05）。研究组的不良反应发生率8．89％显著低于对照组31．82％（P〈0．05）。【结论】罗库溴铵应用于老年LC手术患者不会增加组胺释放量、有利于减轻患者的手术不良反应，同时具有起效快、维持时间长，血流动力学稳定的优点。
[Objective]The purpose of this study is to investigate the anesthetic effects of Rocuronium Bromide in elderly laparoscopic choleeystectomy （LC） patients. [Methods]Eighty-nine patients who intended to perform LC surgical treatment of the liver and gallbladder at our hospital were chosen to be the study subjects. The 89 patients were randomly divided into the research group （ n = 45） and the control group （ n = 44）. The research group used rocuronium bromide, whereas the control group used eisatracurium besilate. The anesthetic effects of the two groups were observed and analyzed. [Results]After administration of the anesthetics at time periods of 1 min, 3 min, 5 min, and 10 min, the histamine concentrations and HR values of the research group were significantly lower than in the control group （ P 〈0.05）. At the same time points, the MAP was significantly higher in the control group than in the research group （ P 〈0.05）. The muscle relaxant onset time in the research group （126.3 ± 9.3）s was significantly shorter than in the control group （194.5 ± 11.0） s （ P 〈0.05）; the duration in the research group （49.2±6.9） min was also significantly longer than in the control group （32.8 ±6.3） min （ P 〈0.05）. The incidence of adverse events in the research group （8.89 % ） was significantly lower than in the control group （31.82 %）（ P 〈0.05）. [Conclusion]The use of Rocuronium Bromide in elderly patients undergoing LC does not increase histamine release, and will help simultaneously reduce the incidence of adverse reactions, have a more rapid onset, long duration, and provide hemodynamic stability.
出处
《医学临床研究》
CAS
2016年第6期1114-1116,共3页
Journal of Clinical Research
