摘要
长链非编码RNA指长度大于200个核苷酸，不具有蛋白编码能力的RNA。20世纪末长链非编码RNA的生物学功能逐渐受到科学界重视，多种研究发现其在胚胎发育、细胞分化、物种进化、新陈代谢、疾病发生等重要生命进程中均发挥着精密而复杂的调控作用。同时，长链非编码RNA可通过多途径多层次广泛参与风湿性疾病发生发展、免疫应答、免疫细胞分化以及免疫系统动态平衡。因此，总结非编码长链RNA在风湿性疾病中的研究进展将有助于更为清晰地了解风湿性疾病的病因。本文将以系统性红斑狼疮、类风湿关节炎、骨关节炎等典型风湿性疾病为例，阐述非编码长链RNA与风湿性疾病的关系。
The long noncoding RNAs refers to RNA transcripts more than 200 nucleotides in length, and do not encode proteins. In the end of the 20th century, the lncRNAs were found to play crucial role in many important biological processes, including embryonic development, cell differentiation, species evolution, metabolism, and disease occurrence by the scientific community. Currently, multiple studies have indicated that long noncoding RNAs have participated in rheumatic diseases, immune response, im- mune cell differentiation, and dynamic balance of the immune system. Therefore, summary of the roles of lncRNAs in rheumatic diseases could be beneficial to understand the pathogenesis of autoimmune diseases. This review article attempts to highlight the recent progresses regarding lncRNAs studies and the relationship between long noncoding RNA and rheumatic diseases by taking systemic lupus erythematosus, rheumatoid arthritis, arthritis and other typical diseases as examples.
出处
《中国医师杂志》
CAS
2016年第6期946-950,共5页
Journal of Chinese Physician
基金
国家自然科学基金（81272047）
四川省教育厅资助科研项目（15ZB0197）
南充市科技支撑项目（14A0061）
川北医学院科研发展计划博士科研启动基金（CBY14-QD-07）
