摘要
双膦酸盐相关性颌骨坏死(BRONJ)是长期使用双膦酸盐治疗骨质疏松症,多发性骨髓瘤以及乳腺癌、前列腺癌和肺癌等其他恶性肿瘤骨转移所引起的骨相关性疾病的严重并发症。BRONJ的发生发展与一些因素密切相关,譬如双膦酸盐的效能、用药方式、牙拔除和不良义齿修复等。美国口腔颌面外科协会在2007年对BRONJ进行了定义、分级并颁布其治疗指南,在2009年和2014年进对其行了更新。尽管BRONJ在国际上引起了广泛的重视,但其发病机制仍不完全清楚,治疗措施也存在着较大的争议。本文就双膦酸盐及其相关性颌骨坏死的机制和治疗等研究进展作一综述。
Bisphosphonate-related osteonecrosis of the jaw（BRONJ） is a severe complication that occurs frequently in patients subjected to long-term bisphosphonate treatment for osteoporosis, multiple myeloma, and other skeletal-related events induced by metastatic malignant diseases, such as breast, prostate, and lung cancers. The development of BRONJ is associated with some risk factors, such as bisphosphonate potency and administration model, dental extraction, and poorfitting dentures. The definition, staging, and treatment guidelines of patients with BRONJ were established by the American Association of Oral and Maxillofacial Surgeons in 2007 and then updated in 2009 and 2014. Although BRONJ has been extensively investigated, the pathogenesis of this disease has yet to be fully elucidated, and corresponding treatments have remained controversial. This article briefl y introduces new insights into the pathogenesis and treatments of BRONJ.
出处
《国际口腔医学杂志》
CAS
北大核心
2016年第4期445-448,共4页
International Journal of Stomatology
基金
江苏省临床医学科技专项项目(BL2013005)
江苏省卫生厅课题项目(H201441)
南京市科技发展计划(201503038)
南京市医学科技发展计划(ykk13150)~~
关键词
双膦酸盐
双膦酸盐相关性颌骨坏死
发病机制
治疗措施
bisphosphonate
bisphosphonate-related of osteonecrosis of the jaw
pathogenesis
treatment measures
