摘要
目的研究高频率10 Hz下重复经颅磁刺激（r TMS）模式对慢性精神分裂患者症阴性症状的疗效及安全性。方法选取2014年1月~2015年6月在我院接受住院治疗的96例慢性精神分裂症患者进行研究,随机将其分为真刺激组和伪刺激组,每组各48例,两组均在维持原有药物治疗种类和剂量基础上接受2周10 Hz r TMS治疗,其中真刺激组刺激经左侧前额叶背外侧皮质部位,伪刺激组进行伪刺激,每周5次,共10次,并随访2周后情况,分别应用阳性与阴性症状量表（PANSS）来进行疗效的评定。结果接受治疗2周后,两组的PANSS评分相比于治疗前明显降低（P〈0.05）,相比于伪刺激组,真刺激组下降更加明显（P〈0.05）;治疗2周后,真刺激组的总有效率为85.42%,伪刺激组的总有效率为77.08%,差异有统计学意义（P〈0.05）。结论 r TMS结合原有抗精神病类的药物可以明显改善慢性精神分裂症患者的阴性症状,且有较好的安全性。
Objective To study the safety and efficacy of different repetitive transcranial magnetic stimulation（r TMS） in the treatment of negative symptoms of chronic schizophrenia.Methods 96 cases of chronic schizophrenic inpatients in our hospital from January 2014 to June 2015 were divided into 48 cases of true-stimulation group and 48 cases of pseudo-stimulation group,two groups were all in maintaining original kinds of drug therapy and dose based on received2 weeks,10 Hz r TMS treatment,which controls stimulation by the left dorsolateral prefrontal cortex in true-stimulation,the pseudo-stimutation group was given the pseudo stimulation.The efficacy of positive and negative symptoms scale（PANSS） were assessed before and after treatment for 2 weeks.Results Two weeks after treatment,the two groups of PANSS score compared to the previous comparative treatment significantly reduced（P〈0.05）,compared to the pseudostimulation group,true-stimulation group decreased more significantly（P〈0.05）.After 2 weeks of treatment,the total efficiency of the true-stimulation group was 85.42%,the total efficiency of the pseudo-stimulation group was 77.08%,the difference was statistically significant（P〈0.05）.Conclusion Repetitive transcranial magnetic stimulation combined with the original class of anti-psychotic drugs can significantly improve the negative symptoms of chronic schizophrenia,and with good security.
出处
《中国当代医药》
2016年第16期65-67,70,共4页
China Modern Medicine
基金
广东省东莞市科技计划医疗卫生类科研一般项目(201310515000025)
关键词
重复经颅磁刺激
精神分裂症
阴性症状
安全性
Repetitive transcranial magnetic stimulation
Schizophrenia
Negative symptoms
Safety
