摘要
目的探讨1,2-二氯乙烷（1,2-DCE）中毒性脑病的临床及影像学特征。方法回顾性分析2009年7月~2015年7月收治的19例1,2-DCE中毒性脑病病例,对其临床特点及影像学资料进行总结分析。结果所有患者均有职业暴漏史,其主要表现为头痛、头晕、恶心、睡眠障碍,乏力、记忆下降、意识障碍、癫痫发作等症状。头颅MRI检查示在皮质下白质、双侧苍白球和小脑齿状核广泛的脑水肿,双侧大脑白质内对称性大片状异常信号影,T_1WI呈低信号,T_2WI高信号,DWI序列上见病灶呈高异常信号,脑水肿、脑肿胀明显。结论根据典型的临床和神经影像学特点,结合职业接触含有l,2-DCE的物质,可诊断1,2-DCE中毒性脑病。
Objective To study the clinical and imaging features of 1,2-dichloroethane（1,2-DCE）-induced toxic encephalopathy. Methods The clinical and imaging features of 19 patients with 1,2-DCE-induced toxic encephalopathy from July 2009 to July 2015. Ninteen patients were summarized and analyzed retrospectively. Results All patients who had been in contact with 1,2-DCE and subsequently had symptoms of headache,dizziness,nausea,sleep disorders,fatigue,memory decline,disturbance of consciousness and seizures. The cranial MRI showed extensive brain edema in either the subcortical white matter,bilateral globus pallidus,and cerebellar nucleus dendatus. Brain MRI showed extensive abnormal signal in cerebral white matters,low signal intensity on T_1WI,high signal intensity on T_2WI and DWI,brain swelling was evident. Conclusion The diagnosis of 1,2-DCE-induced toxic encephalopathy can be confirmed by the typical clinical and neuroimaging characteristics together with a history of occupational exposure to substances contaminated with 1,2-DCE.
出处
《临床神经病学杂志》
CAS
北大核心
2016年第3期206-208,共3页
Journal of Clinical Neurology
