摘要
甘草Glycyrrhizae Radix为豆科植物乌拉尔甘草Glycyrrhiza uralensis、胀果甘草Glycyrrhiza inflata或光果甘草Glycyrrhiza glabra的干燥根或根茎,在临床上常与其他药物联合使用。结合国内外最新研究进展,总结了甘草的主要化学成分与细胞色素P450酶（CYP450）之间的相互作用,包括：（1）CYP酶参与甘草化学成分的代谢过程;（2）甘草化学成分对CYP酶活性的抑制或诱导作用研究;（3）甘草-临床药物联合使用引发潜在的草药-药物相互作用。深入研究甘草的化学成分与主要药物代谢酶之间的相互作用,对于指导中药复方的增效减毒、配伍,以及避免临床草药-药物相互作用等具有重要意义。
Glycyrrhizae Radix is the dry roots or rhizomes of Glycyrrhiza uralensis, G. inflate, and G. glabra, which was used in clinical therapy combined with other drugs. In this paper, we summarized the recent studies in domestic and overseas on the interaction between the components of Glycyrrhizae Radix and the cytochrome P450 enzyme （CYP）, including, 1） the CYP enzymes involved the metabolism of the chemical components of Glycyrrhizae Radix; 2） the inhibition and induction of chemical components of Glycyrrhizae Radix on the activity of CYP enzyme; 3） the progress in the study on the potential herbal-drag interactions in clinical use of Glycyrrhizae Radix preparations. Further studies on the interactions between the chemical components in Glycyrrhizae Radix and the main drug metabolic enzymes have the great significance for guiding the efficacy enhancing, detoxification, and compatibility of Chinese materia medica, which is very important to avoid the clinical herb-drug interactions.
出处
《中草药》
CAS
CSCD
北大核心
2016年第11期1974-1981,共8页
Chinese Traditional and Herbal Drugs
基金
哈尔滨领军人才研究基金(2011RFXYS079)
“973”计划项目(2013CB531800)
国家自然科学基金资助项目(81573501,81503152,81403003)
关键词
甘草
细胞色素P450酶
代谢抑制
药物相互作用
增效减毒
Glycyrrhizae Radix
cytochrome P450 enzyme
metabolic inhibition
herb-drug interactions
efficacy enhancement and toxicity reduction
