摘要
目的探讨恶性甲状腺结节的临床特征和危险因素,为恶性甲状腺结节的筛查提供一定的依据。方法回顾性分析2012年2月‐2015年2月该院收治的253例甲状腺结节手术患者的临床资料,根据病理检查结果分为良性结节组和恶性结节组。对比两组患者的一般情况、超声检查结果及甲状腺功能指标水平。采用非条件多因素Logistic回归分析恶性甲状腺结节危险因素。结果恶性结节组年龄〈40岁、男性、结节内低回声、结节内血流、结节内钙化、纵横径比≥1、伴有颈部淋巴结肿大、边界不清楚、甲状腺过氧化物酶抗体（TPOAb）阳性和甲状腺球蛋白抗体（TGAb）阳性患者比例明显高于良性结节组（P〈0.05）;结节内微钙化（OR=2.475,95%CI 1.425～4.594,P=0.002）和结节内血流（OR=2.868,95%CI 1.765～5.489,P=0.001）是恶性甲状腺结节的独立危险因素。结论年龄〈40岁、男性、超声结节内低回声,结节内有血流、微钙化、纵横径比≥1、边界不规整并伴有颈部淋巴结肿大、TPOAb阳性和TGAb阳性是恶性甲状腺结节的临床特点,其中结节内血流和微钙化是其独立危险因素,应给予足够重视。
【Objective】To explore the clinical characteristics and risk factors of the malignant thyroid nodule, and provide a basis for the screening of malignant thyroid nodules.【Methods】The clinical data of 253 patients with thyroid nodules who received the surgery from February 2012 to February 2015 were retrospectively analyzed. The patients were divided into benign nodule group（n =220） and malignant nodule group（n =33 cases） according to the results of pathological examination. The general situation, the ultrasound results and thyroid function index level of the two groups of patients were compared. Unconditioned multivariable Logistic regression analysis was used to analyze risk factors of malignant thyroid nodules.【Results】The number of patients with clinical features such as age 40 years, male, low echo, blood fl ow, micro calcifi cation, ratio of vertical and horizontal diameter ≥1, cervical lymph node enlargement, boundary irregular, positive thyroid peroxidase antibody（TPOAb） and positive thyroglobulin antibody（TGAb） of the malignant nodule group was signifi cantly higher than that of the benign nodule group（P〈0.05）; Micro calcifi cation in nodules（OR =2.475, 95%CI 1.425 to 4.594, P =0.002） and blood fl ow in nodules（OR =2.868, 95%CI 1.765 to 5.489, P =0.001） were independent risk factors of malignant thyroid nodules.【Conclusion】Age 40 years, male, low echo, blood fl ow, micro calcifi cation, ratio of vertical and horizontal diameter ≥1, cervical lymph node enlargement, boundary irregular, positive TPOAb and positive TGAb are the clinical characteristics of malignant thyroid nodules. The blood fl ow and micro calcifi cation in the nodule are independent risk factors, which should be given enough attention.
出处
《中国医学工程》
2016年第5期10-13,共4页
China Medical Engineering
