摘要
目的分析慢性乙型肝炎病毒（HBV）感染孕妇不NHBeAg血清学状态对不良妊娠结局的影响。方法回顾性调查2010年1月1日至2015年12月31日于南方医科大学南方医院分娩的440例HBsAg（＋）孕妇，将其分为HBeAg（＋）265例，HBeAg（-）175例，随机选取同时期非HBV感染健康孕妇304例作对照组，分析各组不良妊娠结局的差异。另将378例HBV携带孕妇按HBVDNA是否≥1．0×10^6U／L，分为HBVDNA（＋）174例及HBVDNA（-）204例，进一步比较两组不良妊娠结局的差异。结果HBeAg（＋）组比非HBV感染健康孕妇组早产或胎膜早破发生风险更高，HBeAg（-）组与非HBV感染健康孕妇组不良妊娠结局发生风险没有显著差异；HBVDNA（＋）组早产、胎膜早破发生率分别为10．92％、13．22％，HBVDNA（-）组为3．43％、6．37％（P=0．004，P=0．024）。结论HBeAg（＋）孕妇发生早产或胎膜早破风险高于HBeAg（-）孕妇，HBeAg（＋）可作为预测早产或胎膜早破发生风险的高危因素。
Objective To analyze the incidence of adverse pregnancy outcomes among pregnant women with different serum HBV antigen status. Methods The retrospective cohort study population comprised pregnant women who were admitted to Nanfang Hospital, Southern Medical University, Guangdong, China for delivery from January 1, 2010 to December 31, 2015.According to e-antigen status, 440 cases of positive HBsAg were divided into HBeAg （＋） group （265 cases） and HBeAg （-） group （175 cases）. A total of 304 cases without chronic hepatitis B in pregnancy were included as control group. The difference in the adverse pregnancy outcome was analyzed among the groups. According to HBV DNA≥1.0×10^6 U/L,378 cases were divided into HBV DNA（＋） group （174 cases） and HBV DNA （-） group （204 cases）. Differences between groups were compared. Results HBeAg （＋） groups had significant increased uORs and aORs regarding preterm birth and premature rupture of membrane when compared to the controls. There was no difference between HBeAg（-） group and the control group. The incidence of preterm birth or preterm rupture of membranes in the HBV DNA（＋） group were 10.92% and 13.22%, higher than the 3.43% and 6.37% of the HBV DNA（-） group （P=0.004, P=0.024）.Conclusion Pregnant women with HBeAg （＋） are at higher risks of preterm birth or premature rupture of membrane. So HBeAg status may be a simple marker for clinical implication as a risk predictor of preterm birth or premature rupture of membrane.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2016年第7期680-684,共5页
Chinese Journal of Practical Gynecology and Obstetrics
基金
国家自然科学基金(81401208)
关键词
乙型肝炎
孕妇
HBEAG阳性
不良妊娠结局
hepatitis B
pregnant women
HBeAg positive
adverse pregnancy outcomes
