摘要
目的观察冠心病合并亚临床甲减患者左旋甲状腺素片(优甲乐)替代治疗血清指标水平变化及探讨MPO、C反应蛋白(hs-CRP)等与亚临床甲减的关系。方法收集2013年2月至2015年12月冠心病合并亚临床甲减患者50例(观察组),冠心病无亚临床甲减患者50例(对照组)。观察组给予左旋甲状腺素片替代治疗。分别测定观察组和对照组治疗前后血促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、血甘油三酯(TG)、总胆固醇(TC)、髓过氧化物酶(MPO)及超敏hs-CRP的水平。结果治疗前观察组血TSH、TG、TC、MPO、hs-CRP水平均显著高于对照组(P<0.05),FT3、FT4差异无统计学意义(P>0.05);治疗后观察组TSH、TG、TC、MPO、hs-CRP水平均显著低于治疗前水平(P<0.05),与对照组比较差异均无统计学意义(P>0.05)。结论对冠心病合并亚临床甲减患者行左旋甲状腺素片替代治疗可以有效降低血TSH、TG、TC、MPO及hs-CRP水平,亚临床甲减会升高冠心病患者MPO、hs-CRP水平,影响冠心病的发展。
Objective TO investigate the changes of serum indexes in coronary heart disease patients complicated with subclinical hypothyroidism treated by levothyroxine （euthyrox） replacement therapy. Methods Fifty coronary heart disease patients complicated with subclinical hypothyroidism were treated with levothyroxine as study group, and 50 coronary heart disease patients without subclinical hypothyroidism served as control group. The levels of thyroid stimulating hormone （TSH）, free triiodothyronine（FT3）, free thyroxine（FT4）, serum triglyceride（TC）, total cholesterol（TG）, myeloperoxidase （MPO） and high sensitive C reactive protein（hs-CRP） were detected before and after treatment in both groups. Results Before treatment, serum TSH, TG, TC, hs-CRP and MPO levels were significantly higher in study group than those in control group （P〈0.05）, while there were no significant difference in FT4 and FT3 levels between two groups （P 〉0.05）. After treatment, the levels of TSH, TG, TC, MPO and hs-CRP in study group were significantly lower than those before treatment （P〈0.05）, and there was no significant difference compared with control group（P 〉0.05）. Conclusion Levothyroxine replacement therapy can effectively reduce the levels of TSH, TG, TC, MPO and hs-CRP in coronary heart disease patients complicated with subclinical hypothyroidism.
出处
《浙江医学》
CAS
2016年第11期822-825,共4页
Zhejiang Medical Journal
