摘要
目的:了解全国质子泵抑制剂的应用现状、趋势及应用中的风险。方法:借助2010—2013年全国医院质子泵抑制剂临床应用数据,查阅近年来国内、外相关文献,对质子泵抑制剂的应用现状、趋势进行归纳和分析,并探讨质子泵抑制剂应用中的风险。结果:2013年全国消化系统用药销售金额为267.5亿元,品种为395种,其中质子泵抑制剂有6种,其销售金额为67.8亿元,占消化系统用药总销售金额的25.35%;2010—2013年全国质子泵抑制剂口服制剂的用药频度较注射剂增长迅猛,注射剂销售金额的增幅高于口服制剂;奥美拉唑与泮托拉唑仍是主要应用品种,埃索美拉唑和兰索拉唑的用药频度、销售金额均增幅较大、增速较快。质子泵抑制剂临床应用存在的问题主要体现在超适应证应用、超剂量和疗程应用、溶剂选择不适宜、服药时辰不正确及联合用药不适宜等方面。结论:应加强对质子泵抑制剂临床应用的监管,制订相关临床应用指导原则,权衡患者获益是否大于可能出现的风险,保证最佳用药方案,以促进质子泵抑制剂的合理应用。
OBJECTIVE：To investigate the application status , trend , and risks of proton pump inhibitors . METHODS：The application status and trend were summarized and analyzed and the risks were investigated through looking up the clinical application data of proton pump inhibitors in the national hospitals and retrieving the related domestic and international literatures .RESULTS： The consumption sum of drugs in the national digestive system was 26.75 billion yuan , with 395 categories; among which there were 6 categories of proton pump inhibitors , with consumption sum of 6.78 billion yuan , accounting for 25.35%of the total consumption sum .The DDDs of oral proton pump inhibitors increased more significantly than the injections during 2010-2013, the consumption sum of the injections were higher than that of oral prescriptions .Meanwhile , omeprazole and pantoprazole were the main application drugs , and the amplification of DDDs , consumption sum of esomeprazole and lansoprazole were relatively high .The main problems of clinical application of proton pump inhibitors were performed as over indications , over dosage and treatment course, improper selection of solvent , incorrect administration time and improper drug combination , etc. CONCLUSIONS：It is necessary to strengthen the supervision of application of proton pump inhibitors in clinic , formulate the related guide principles for application of proton pump inhibitors , balance the benefit of patients over the possible risks, so as to ensure the best scheme of medication and promote the rational application of proton pump inhibitors .
出处
《中国医院用药评价与分析》
2016年第6期817-820,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
