摘要
目的观察小牛血清去蛋白注射液联合丁苯酞治疗急性缺血性脑梗死的临床效果。方法选取2013年5月—2015年5月唐山康复医疗中心收治的急性缺血性脑梗死患者250例,随机分为对照组和治疗组,每组各125例。对照组静脉滴注丁苯酞氯化钠注射液,100 mL/次,2次/d,每次静脉滴注时间大于50 min。治疗组在对照组治疗基础上静脉滴注小牛血清去蛋白注射液,20 mL溶于生理盐水250 mL,1次/d。两组均连续治疗14 d。观察两组的临床疗效,同时比较两组治疗前后临床神经功能缺损程度(NDS)评分、超氧化物歧化酶(SOD)活性和丙二醛(MDA)的变化情况。结果治疗后,对照组和治疗组的总有效率分别为69.6%、86.4%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者NDS评分、MDA均显著降低,SOD显著升高,同组治疗前后差异具有统计学意义(P<0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论小牛血清去蛋白注射液联合丁苯酞治疗急性缺血性脑梗死临床疗效较好,能够改善患者神经功能缺损,安全性好,具有一定的临床推广应用价值。
Objective To observe the clinical effects of Deproteinised Calf Blood Serum Injection combined with butylphthalide in treatment of acute ischemic cerebral infarction. Methods Patients（250 cases） with acute ischemic cerebral infarction in Tangshan Rehabilitation Medical Center from May 2013 to May 2015 were selected. The patients were randomly divided into control group and treatment group, and each group had 125 cases. The patients in the control group were iv administered with Butylphthalide and Sodium Chloride Injection, 100 mL/time, twice daily, and intravenous drip time was longer than 50 min. The patients in the treatment group were iv administered with Deproteinised Calf Blood Serum Injection on the basis of the control group, 20 mL added into normal saline 250 mL, once daily. The patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the changes of NDS score, SOD, and MDA in two groups before and after treatment were compared. Results After treatment, the total efficacies in the control and treatment groups were 69.6% and 86.4%, respectively, and there were differences between two groups（P〈 0.05）. After treatment, NDS scores and MDA in two groups were significantly decreased, and SOD was significantly increased, and the difference was statistically significant in the same group（P〈 0.05）. After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups（P〈 0.05）. Conclusion Deproteinised Calf Blood Serum Injection combined with butylphthalide has clinical curative effect in treatment of acute ischemic cerebral infarction, and can improve nerve function defect with good safety, which has a certain clinical application value.
出处
《现代药物与临床》
CAS
2016年第6期797-800,共4页
Drugs & Clinic
