摘要
Notch-1信号通路在细胞分化、发育以及增殖、凋亡方面起重要作用,并参与肿瘤的发生发展,与肿瘤的侵袭、运动和转移过程密切相关。活化的Notch-1信号通路能够直接或间接调控细胞的增殖和迁移,促进肿瘤细胞发生上皮细胞间充质转换,并维持其间充质特性,增强肿瘤细胞的黏附能力。同时,Notch信号通路与PI3K/Akt、NF-κB等途径交互作用,将信号级联放大,从而加强调控肿瘤细胞的恶性行为。多种实体瘤中存在异常活化的Notch-1信号通路。从Notch的结构和功能、Notch-1信号通路与肿瘤发生和转移的关系、Notch-1调控肿瘤转移的分子机制与调控网络和以Notch为靶点的肿瘤治疗5个方面进行综述。阐明Notch-1信号通路在肿瘤转移过程中的作用与调控机制以及目前针对Notch-1信号通路的治疗策略,能够为肿瘤的病理机制和临床治疗研究提供参考信息。
Notch-1 signaling pathway is responsible for cell differentiation,development,proliferation and apoptosis. Recent studies show that Notch-1 signaling pathway is also involved in cancer progression,including cell invasion,motility and cancer metastasis. Activation of Notch-1 signaling pathway can directly or indirectly induce cell proliferation and migration. In tumor cells,activation of Notch-1 facilitates epithelial-mesenchymal transition（ EMT）,keeps its mesenchyme characteristics and induces cell adhesion. Notch-1 signaling pathway also crosstalks with other pathways to regulate cell fate,such as PI3 K / Akt,NF-κB pathways. The evidence shows that aberrant Notch-1 activation has been found in different solid tumors,which participates in regulating tumor metastasis. In this review,the Notch structure and function,Notch-1 signal and tumorigenesis,tumor metastasis via Notch-1 signaling,and Notch-1 signaling targeted-therapy were comprehensively summarized. To clarify the roles of Notch-1 signal pathway in tumor metastasis and its regulatory mechanisms as well as the current treatment strategies for Notch-1 signal pathway will provide references for studies on pathomechanism and clinical treatment of cancers.
出处
《医用生物力学》
EI
CAS
CSCD
北大核心
2016年第3期284-290,共7页
Journal of Medical Biomechanics
基金
国家自然科学基金项目(11272083,31470906,11502049)
四川省杰出青年基金项目(2014JQ0008)
