摘要
目的：为临床合理使用抗甲状腺药物提供参考。方法：对我院2004年5月-2015年12月上报的甲巯咪唑和丙硫氧嘧啶引起的药品不良反应（ADR）报告进行回顾性分析,分别从患者的年龄、性别、潜伏期、临床表现等方面进行统计和分析。结果：60例ADR患者中,女性多于男性,男女性别比例为1∶2.75,平均年龄为（39.7±13.4）岁,83.3%的ADR发生于20~59岁;66.7%的ADR发生在用药30 d内。急性药物性肝病（66.7%,40/60）和中性粒细胞减少（25%,15/60）是最常见的临床表现。甲巯咪唑和丙硫氧嘧啶引起急性药物性肝病占所有ADR的比例差异有统计学意义（P〈0.05）,丙硫氧嘧啶高于甲巯咪唑;而引起粒细胞缺乏症的比例差异无统计学意义（P〉0.05）。结论：在使用抗甲状腺药物治疗前后,应检查肝功能和中性粒细胞数目,并进行监测及随访,以确保患者安全用药。
OBJECTIVE： To provide reference for rational use of antithyroid drugs （ATD） in the clinic. METHODS： Retro- spective analyzed 60 cases of adverse reaction caused by Methimazole and Propylthiouracil in terms of age, gender, incubation peri- od,organ or system involved and clinical manifestation, which were searched from 2004 May-2014 Dec. in First Affiliated Hospital of Soochow University. RESULTS： Among 60 ADR cases, male was more than female, and the ratio of male to female was 1：2.75; average age was（39.7 ＋ 13.4）years old, and 83.3% ADR occurred between 20 and 59 years old; 66.7% ADR occurred within 30 days. Most common clinical manifestations were drug-induced liver disease （66.7%, 40/60） and neutropenia （25%, 15/60）. There was statistical significance in the proportion of drug-induced liver disease caused by methimazole and propylthiouracil in all ADR cases （P〈0.05）, there was no statistical significance in the proportion of agranulemia caused by these two drugs （P〉0.05）. CON- CLUSIONS： Before and after the treatment of antithyroid drugs, it＇s necessary to check hepatic function and the number of neutro- phile granulocyte, and we should monitor and follow up it to ensure the safe use of drugs.
出处
《中国药房》
CAS
北大核心
2016年第20期2783-2786,共4页
China Pharmacy
