摘要
目的了解甘肃省临泽县居民重点人群碘摄入量的现况和甲状腺功能状态,为食盐碘化量的标准提供科学依据。方法采用分层抽样方法按东、南、西、北、中随机选择1个乡,每个乡选择8-10岁儿童20名（男女各半）、18-49岁成年男性、未孕育龄妇女、孕妇和哺乳期妇女各10名,测定血清TSH、FT4、FT3、甲状腺过氧化物酶抗体（Tm Ab）、甲状腺球蛋白抗体（TGAb）及尿碘;同时测定所选乡镇所有水源水的水碘含量,调查3个乡60名8-10岁儿童家庭食盐摄入量。结果水碘中位数为6.18μg/L,盐碘中位数为28.8 mg/kg,合格碘盐食用率为99.0%,人均日摄盐量为（4.7±0.9）mg/kg;8-10岁儿童、18-49岁男性、未孕育龄妇女、孕妇和哺乳期妇女5种人群尿碘中位数分别为180.6μg/L、161.0μg/L、199.3μg/L、135.1μg/L和104.9μg/L,不同人群的TSH（χ^2=42.580）、FT4（F=23.375）、FT3（F=51.859）、TG Ab（χ^2=15.594）和TM Ab（χ^2=14.675）差异均有统计学意义（均P〈0.05）;8-10岁儿童的TSH、FT4和FT3均高于其他人群,差异有统计学意义（χ^2=12.680,P〈0.05）,育龄妇女的TGAb和TMAb阳性率最高为20.4%,差异有统计学意义（χ^2=31.560,P〈0.05）;各人群甲状腺功能异常主要为亚临床甲状腺功能减退症和亚临床甲状腺功能亢进症,8-10岁儿童亚临床甲状腺功能减退症最高为7.8%,差异有统计学意义（χ^2=2.758,P〈0.05）,未孕育龄妇女亚临床甲状腺功能亢进症最高为7.4%,差异有统计学意义（χ^2=6.445,P〈0.05）。结论临泽县是碘缺乏地区,在目前碘摄入量下,尿碘显示孕妇和哺乳期妇女碘营养不足,8-10岁儿童和未孕育龄妇女甲状腺疾病潜在的危险性相对较高。
Objective To understand current situation of iodine intake and thyroid function status of key crowds of residents in Linze county, Gansu province, to provide scientific basis for standard of iodination contents of table salt. Methods One township was selected randomly with stratified sampling method according to the five directions. From each township,20 children aged 8 to 10 years（half of boys and girls）, 10 of adult men aged 18 to 49 years, women at reproductive age without pregnancy, pregnant women and women at lactation were selected respectively to detect serum TSH, FT4, FT3, Tm Ab,TGAb and urine iodine. Meanwhile, iodine content in source water was also determined in the selected small towns. Intake amount of table salt from 60 children aged 8 to 10 years at 3 townships was investigated. Results Median was 6.18 μg/L of the water iodine and 28.8 mg/kg of the salt iodine, with the intake rate of qualified iodized salt of 99.0%, daily salt intake amount of each person of（4.7±0.9） mg/kg. The median of urine iodine was 180.6 μg/L, 161.0 μg/L, 199.3 μg/L, 135.1 μg/L and 104.9 μg/L for the children aged 8 to 10 years, adult men aged 18 to 49 years, women at reproductive age without pregnancy, pregnant women and women at lactation. There was statistical difference（P〈0.05） in TSH（χ^2=42.580）, FT4（F=23.375）, FT3（F=51.859）, TGAb（χ^2=15.594）, and TMAb（χ^2=14.675）. TSH, FT4 and FT3 of children aged 8 to 10 years were higher than those of the other crowds, with statistical difference（χ^2=12.680,P〈0.05）. Positive rate of TG Ab and TM Ab was the highest of 20.4% in women at reproductive age, with statistical difference（χ^2=31.560,P〈0.05）. Thyroid dysfunction of the crowds was mainly subclinical hypothyroidism and subclinical hyperthyroidism. Subclinical hypothyroidism was the highest of 7.8% in the children aged 8 to 10 years, with statistical difference（χ^2=2.758, P〈0.05）, while subclinical hyperthyroidism was the highest of 7.4% in the women at reproductive age without pregnancy, with statistical difference（χ^2=6.445, P〈0.05）. Conclusions Linze is iodine deficiency area. Under the situation of iodine intake amount, the result shows that there is short of iodine nutrition in pregnant women and women at lactation. Potential risk of thyroid disease is high in the children aged 8 to 10 years and women at reproductive age without pregnancy.
出处
《疾病预防控制通报》
2016年第3期37-39,48,共4页
Bulletin of Disease Control & Prevention(China)
关键词
重点人群
碘营养
甲状腺功能
Key crowd
Iodine nutrition
Thyroid function
