摘要
抑郁症在全球范围内高发,目前尚无有效的治疗手段,使其成为全球性卫生问题之一。抑郁症动物模型作为疾病机理研究以及药物筛选的主要手段,一直以来备受关注,现有的抑郁模型创新性地融合了比较行为学以及最新的分子生物学等相关技术。本文将结合模型的表面效度、结构效度及预测效度对现有的抑郁症动物模型及发病机制研究的最新进展进行综述,主要包括应激模型、损伤模型、化学诱导模型及转基因模型,这些模型均能不同程度的模拟人抑郁症的特征,在抗抑郁药物开发及发病机理研究中发挥重要作用。
The incidence of depressive illness is high worldwide,and the inadequacy of currently available drug treatments contributes to the significant health burden associated with depression. Animal models of depression used as the main methods to study the pathogenesis mechanism and select effective drugs receive increasing concerns. Current popular models of depression creatively merge ethologically valid behavioral assays with the latest technological advances in molecular biology. In this context,this study aims to review the animal models of depression and pathogenesis related with face validity,construct validity,and predictive validity of these models. These models include stress-induced models,injury-induced models,drug-induced models and transgenic models which all mimic the depression symptoms of human to some degree and are of great value for developing new antidepressant drugs and studying the pathogenesis of this disease.
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2016年第3期321-326,共6页
Acta Laboratorium Animalis Scientia Sinica
基金
国家科技支撑计划项目(编号:2014BAI01B01)
