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EGFR-TKI治疗“窗口期”联合放疗治疗局部大肿块非小细胞肺癌的临床观察 被引量:3

Clinical Observation of EGFR-TKI Combined with Radiotherapy in Treating Localized Large Pulmonary Mass of Non-small Cell Lung Cancer during EGFR-TKI Treatment " Window Period"
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摘要 探讨EGFR-TKI治疗"窗口期"联合放疗治疗局部大肿块非小细胞肺癌的可行性。分析2011年6月-2015年6月收治的非小细胞肺癌患者10例,均为EGFR基因突变阳性的局部大肿块,首先行TKI治疗,在其"窗口期"内给予恰当的放疗,并评估疗效。结果:(1)TKI治疗1个月后,10例患者肺部肿瘤均不同程度缩小,随即4例完成了常规放疗,6例完成了体部立体定向放射治疗;(2)放疗结束1个月后评估,CR 2例,PR 8例,不良反应可耐受;(3)至随访结束,6例出现耐药,中位PFS为28个月(范围为13个月-33个月)。TKI治疗"窗口期"联合放疗治疗局部大肿块非小细胞肺癌,可增加根治性放疗的机会,并有延缓TKI耐药的可能,值得进一步研究。 To investigate the feasibility of EGFR-TKI combined with radiotherapy in the treatment of non-small cell lung cancer with localized large pulmonary mass during EGFR-TKI treatment " window period",the authors analyzed 10 cases of non-small cell lung cancer from June of 2011 to 2015 which were all EGFR-mutated patients with locally large pulmonary mass.All cases were firstly treated with TKI,and then treated with radiotherapy within the TKI treatment "window period",and the therapeutic effect was evaluated.(1)After a month of TKI treatment,the tumors of the 10 patients were evaluated to be more or less decreased.Then 4 cases accepted conventional radiotherapy,6cases accepted stereotactic body radiotherapy;(2)1 month after the end of radiotherapy,2 cases was evaluated to CR,8 cases was evaluated to PR,and toxicities were generally tolerated;(3)Until the end the follow-up,6cases out of 10 got drugresistance,their median PFS was 28 months(range,13 months-33 months).The combination of radiotherapy and TKI during the " window period" can increase the opportunities of radical radiotherapy for localized large mass of non-small cell lung cancer patients,and may decrease the chance of drug resistance.It's a problem worth studying.
出处 《医学与哲学(B)》 2016年第5期42-45,共4页 Medicine & Philosophy(B)
基金 2012年度宜宾市"一抓一"100万科技工程项目 项目编号:2012ZSF007 2013年度宜宾市重点科技计划项目资金 项目编号:2013SF011
关键词 非小细胞肺癌 表皮生长因子受体-酪氨酸激酶抑制剂 放疗 窗口期 non-small cell lung cancer epidermal growth factor receptor-tyrosine kinase inhibitor radiotherapy window period
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参考文献30

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